2. MAPK/ERK Pathway
  3. p38 MAPK
  4. p38α-IN-12

p38α-IN-12 is an orally bioavailable p38α MAPK inhibitor, with an IC50 of 0.11 nM and a Ki of 0.2 nM against human targets. p38α-IN-12 inhibits the production of TNFα in cellular systems and exerts in vivo efficacy in acute mouse models.

For research use only. We do not sell to patients.

p38α-IN-12

p38α-IN-12 Chemical Structure

CAS No. : 630106-85-3

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

p38α-IN-12 Related Antibodies

Top Publications Citing Use of Products

View All p38 MAPK Isoform Specific Products:

View All Isoforms
p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

p38α-IN-12 is an orally bioavailable p38α MAPK inhibitor, with an IC50 of 0.11 nM and a Ki of 0.2 nM against human targets. p38α-IN-12 inhibits the production of TNFα in cellular systems and exerts in vivo efficacy in acute mouse models[1].

In Vitro

p38α-IN-12 (compound 2x) inhibits LPS-induced TNFα production in human peripheral blood mononuclear cells with an IC50 of 6 nM[1].
p38α-IN-12 does not significantly inhibit human CYP 450 isoforms 1A2, 2C9, 2C19, 2D6, or 3A4, with IC50 values >40 μM for each[1].
p38α-IN-12 shows excellent metabolic stability in human and rat liver microsomes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

p38α-IN-12 Related Antibodies
Parmacokinetics
Species Dose Route Bioavailability Clearance (CL) Vd T1/2
Mice[1] 10 mg/kg p.o. 60 % 0.3 1.3 L/kg 4.1 h
Molecular Weight

411.43

Formula

C22H17N7O2
CAS No.
SMILES

O=C(NC1=NOC=C1)C2=CC=C(C(=C2)NC3=NC=NC4=C3C=NN4C=5C=CC=CC5)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

p38α-IN-12 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

p38α-IN-12630106-85-3p38 MAPKhuman peripheral blood mononuclear cellshuman CYP 450 isoforms 1A2human liver microsomesacute murine modelhuman CYP 450 isoforms 3A4human CYP 450 isoforms 2C9human CYP 450 isoforms 2D6TNFαhuman CYP 450 isoforms 2C19p38α MAP kinaseInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
p38α-IN-12
Cat. No.:
HY-183042
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.