630106-85-3
630106-85-3
Chemical Structure
p38α-IN-12
- CAS No.: 630106-85-3
- Formula:C22H17N7O2
- Molecular Weight:411.43
IUPAC Name: N-(isoxazol-3-yl)-4-methyl-3-((1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)benzamide
InChIKey: VMOVZKURWYNTLN-UHFFFAOYSA-N
SMILES: O=C(NC1=NOC=C1)C2=CC=C(C(=C2)NC3=NC=NC4=C3C=NN4C=5C=CC=CC5)C
Biological Activity: p38α-IN-12 is an orally bioavailable p38α MAPK inhibitor, with an IC50 of 0.11 nM and a Ki of 0.2 nM against human targets. p38α-IN-12 inhibits the production of TNFα in cellular systems and exerts in vivo efficacy in acute mouse models[1].
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p38α-IN-12 | p38α-IN-12 is an orally bioavailable p38α MAPK inhibitor, with an IC50 of 0.11 nM and a Ki of 0.2 nM against human targets. p38α-IN-12 inhibits the production of TNFα in cellular systems and exerts in vivo efficacy in acute mouse models. | |||||||||||||||||||||
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References
Keywords
