2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Immunology/Inflammation Anti-infection
  3. HSP Interleukin Related Enterovirus
  4. Pochonin D

Pochonin D ((+)-Pochonin D) is an inhibitor of heat shock protein 90 (Hsp90) with antiviral and anti-inflammatory activities. Pochonin D inhibits Hsp90, affects the homeostasis, folding and assembly processes of viral proteins, and reduces the replication capacity of viruses. Pochonin D reduces the infiltration of inflammatory cells, decreases the secretion of inflammatory cytokines such as TNF-α and IL-1β, and alleviates inflammatory responses. Pochonin D is a promising candidate for research on human rhinovirus (HRV) infection and cancer.

For research use only. We do not sell to patients.

Pochonin D

Pochonin D Chemical Structure

CAS No. : 544712-82-5

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Pochonin D Related Antibodies

Top Publications Citing Use of Products

View All HSP Isoform Specific Products:

View All Isoforms
HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

View All Interleukin Related Isoform Specific Products:

View All Isoforms
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Pochonin D ((+)-Pochonin D) is an inhibitor of heat shock protein 90 (Hsp90) with antiviral and anti-inflammatory activities. Pochonin D inhibits Hsp90, affects the homeostasis, folding and assembly processes of viral proteins, and reduces the replication capacity of viruses. Pochonin D reduces the infiltration of inflammatory cells, decreases the secretion of inflammatory cytokines such as TNF-α and IL-1β, and alleviates inflammatory responses. Pochonin D is a promising candidate for research on human rhinovirus (HRV) infection and cancer[1][2].
In Vitro

Pochonin D (0.4-10 μM; 2 days) potently inhibits HRV1B replication and CPE in Hela cells, with 90% antiviral activity at 2 μM and 10 μM (for 2 days), and reduces viral 5′NCR mRNA levels at 10 μM (48 h post-infection), while showing no cytotoxicity at tested concentrations[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pochonin D Related Antibodies
In Vivo

Pochonin D (200 µg/kg; i.p.; twice) significantly inhibits HRV1B replication, reduces pulmonary and BALF pro-inflammatory mediator levels, decreases inflammatory cell infiltration, and ameliorates lung and tracheal pathology in HRV1B-infected mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c (4-5 weeks of age)[2]
Dosage: 200 µg/kg
Administration: i.p.; twice (1 hour pre-infection and 4 hours post-infection)
Result: Reduced relative HRV1B NCR gene expression in lung tissue compared to vehicle-treated infected mice.
Decreased lung levels of CCL2, CXCL1, IL-1β, TNF-α, and IL-6 to near naïve control levels.
Significantly reduced BALF levels of CXCL1, IL-1β, TNF-α, and IL-6 compared to vehicle-treated infected mice.
Significantly lowered the number (1×104 cells) and percentage of myeloid-derived suppressor cells (MDSCs) in BALF compared to vehicle-treated infected mice.
Reduced lung edema, hemorrhage, and inflammatory cell infiltration, with lower histological scores compared to vehicle-treated infected mice.
Ameliorated tracheal airway cilia damage relative to vehicle-treated infected mice.
Molecular Weight

350.79

Formula

C18H19ClO5
CAS No.
SMILES

ClC1=C2C(C(O[C@@H](C/C=C/CC/C=C/C(C2)=O)C)=O)=C(C=C1O)O
Structure Classification
Initial Source

Humicola sp. FO-2942
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Pochonin D Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pochonin D544712-82-5(+)-Pochonin DHSPInterleukin RelatedEnterovirusHeat shock proteinsILRhinovirusHRVHRVsHEVHEVsHRV1Bnascent polypeptide foldingHsp90inflammatory cytokineHela cellsviral replicationrespiratory tractinnate immune cellhuman rhinovirus infectionchemokineInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Pochonin D
Cat. No.:
HY-N14780
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.