Susalimod
Susalimod is an immunomodulating agent and Sulfasalazine (HY-14655) analogue. Susalimod decreases LPS-induced TNF-alpha mouse serum levels.
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- CAS No.: 149556-49-0
- Formule: C21H16N2O5S
- Masse moléculaire:408.43
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| U-87MG ATCC | IC50 |
70 μM
Compound: 16
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Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid scintillation counting
Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid scintillation counting
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[PMID: 21889337] |
Chemical Information
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CAS No. 149556-49-0
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Masse moléculaire 408.43
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Formule C21H16N2O5S
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SMILES
O=C(O)C1=CC(C#CC2=CC=C(S(=O)(NC3=NC=CC=C3C)=O)C=C2)=CC=C1O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Gozzi P, et al. Pharmacokinetic-pharmacodynamic modeling of the immunomodulating agent susalimod and experimentally induced tumor necrosis factor-alpha levels in the mouse. J Pharmacol Exp Ther. 1999 Oct;291(1):199-203. [Content Brief]
[2]. Påhlman , et al. Extensive biliary excretion of the sulfasalazine analogue, susalimod, but different concentrations in the bile duct in various animal species correlating to species-specific hepatobiliary toxicity. Pharmacol Toxicol. 1999 Sep;85(3):123-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Susalimod Related Classifications
HY-100485 Related Classifications
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