149556-49-0
149556-49-0
Chemical Structure
Susalimod
- CAS No.: 149556-49-0
- Formula:C21H16N2O5S
- Molecular Weight:408.43
IUPAC Name: 2-hydroxy-5-((4-(N-(3-methylpyridin-2-yl)sulfamoyl)phenyl)ethynyl)benzoic acid
InChIKey: WJLQPSZXCOYTHS-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC(C#CC2=CC=C(S(=O)(NC3=NC=CC=C3C)=O)C=C2)=CC=C1O
Biological Activity: Susalimod is an immunomodulating agent and Sulfasalazine (HY-14655) analogue. Susalimod decreases LPS-induced TNF-alpha mouse serum levels[1][2].
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Susalimod | Susalimod is an immunomodulating agent and Sulfasalazine (HY-14655) analogue. Susalimod decreases LPS-induced TNF-alpha mouse serum levels. | |||||||||||||||||||||
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References
- [1]. Gozzi P, et al. Pharmacokinetic-pharmacodynamic modeling of the immunomodulating agent susalimod and experimentally induced tumor necrosis factor-alpha levels in the mouse. J Pharmacol Exp Ther. 1999 Oct;291(1):199-203. [Content Brief]
- [2]. Påhlman , et al. Extensive biliary excretion of the sulfasalazine analogue, susalimod, but different concentrations in the bile duct in various animal species correlating to species-specific hepatobiliary toxicity. Pharmacol Toxicol. 1999 Sep;85(3):123-9. [Content Brief]
Keywords
