2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. TLR7 agonist 18

TLR7 agonist 18 (Compound 21a) is a selective Toll-like receptor 7 (TLR7) agonist with an EC50 of 7.8 μM. TLR7 agonist 18 is not cytotoxic to hTLR7 cotransfected HEK293 cell lines and can induce the secretion of several cytokines, including IL-1β, IL-12p70, IL-8, and TNF-α. TLR7 agonist 18 can be used in vaccine, asthma, allergy and anti-cancer research.

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TLR7 agonist 18 Chemical Structure

TLR7 agonist 18 Chemical Structure

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TLR7 agonist 18 Related Antibodies

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Description

TLR7 agonist 18 (Compound 21a) is a selective Toll-like receptor 7 (TLR7) agonist with an EC50 of 7.8 μM. TLR7 agonist 18 is not cytotoxic to hTLR7 cotransfected HEK293 cell lines and can induce the secretion of several cytokines, including IL-1β, IL-12p70, IL-8, and TNF-α. TLR7 agonist 18 can be used in vaccine, asthma, allergy and anti-cancer research[1].

IC50 & Target

EC50: 7.8 μM (TLR7)[1].
Molecular Weight

380.34

Formula

C18H16F4N4O
SMILES

FC(C1=NC(N2CC(C)CCC2)=C3C(ON=C3C4=CC=C(F)C=C4)=N1)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TLR7 agonist 18 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TLR7 agonist 18Toll-like Receptor (TLR)Vaccinesasthmaallergiesanti-cancerimmune regulationIL-1βIL-12p70IL-8TNF-αInhibitorinhibitorinhibit

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