YARA peptide

YARA peptide is a cell-penetrating MK2 inhibitory peptide. YARA peptide limits MK2 kinase activity by competing with natural substrates for binding to MK2, and inhibits MK3 kinase activity. YARA peptide reduces phosphorylation of HSP27 at Ser15 downstream of MK2. YARA peptide inhibits pro-inflammatory cytokine expression, reducing IL-1β, TNF-α and IFN-γ secretion as well as IL-1β, IL-6 and TNF-α levels. YARA peptide is taken up via a caveolae-mediated, energy- and cholesterol-dependent endocytic pathway, and is taken up by mesothelial cells. YARA peptide can be used for research on atopic dermatitis.

• Data Sheet (278 KB)
• Custom Peptide Synthesis