Trichodimerol
Trichodimerol (BMS-182123) is a TNF-α promoter inhibitor that inhibits the activity of lipopolysaccharide-induced cytokine secretion. Trichodimerol inhibits lipopolysaccharide-induced TNF-α promoter activity, reduces steady-state TNF-α mRNA expression, and does not alter the stability of TNF-α mRNA. Trichodimerol inhibits lipopolysaccharide-induced TNF-α secretion in murine and human immune cells. Trichodimerol reduces lipopolysaccharide-induced IL-1β secretion by 25%-50% in vitro. Trichodimerol does not alter total protein synthesis or constitutive lysozyme secretion at effective concentrations. Trichodimerol can be used for the research of septic shock.
For research use only. We do not sell to patients.
- CAS No.: 145174-90-9
- Formula: C28H32O8
- Molecular Weight:496.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Jurkat | IC50 |
28.5 μM
Compound: 16
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Cytotoxicity against human Jurkat cells after 24 hrs by MTT assay
Cytotoxicity against human Jurkat cells after 24 hrs by MTT assay
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[PMID: 21146414] |
| K562 | IC50 |
47.8 μM
Compound: 16
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Inhibition of NF-kappaB activity in TNFalpha-stimulated human K562 cells after 24 hrs by luciferase reporter gene assay
Inhibition of NF-kappaB activity in TNFalpha-stimulated human K562 cells after 24 hrs by luciferase reporter gene assay
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[PMID: 21146414] |
| K562 | IC50 |
74.4 μM
Compound: 16
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Cytotoxicity against human K562 cells after 24 hrs by MTT assay
Cytotoxicity against human K562 cells after 24 hrs by MTT assay
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[PMID: 21146414] |
| U-937 | IC50 |
16.5 μM
Compound: 16
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Cytotoxicity against human U937 cells after 24 hrs by MTT assay
Cytotoxicity against human U937 cells after 24 hrs by MTT assay
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[PMID: 21146414] |
Trichodimerol (BMS-182123) (concentrations leading to >99% inhibition; ~20 h) concentration-dependently inhibits LPS-induced TNF-α production in murine RAW 264.7 macrophages with an IC50 of 600 ng/mL[1].
Trichodimerol (BMS-182123) (0.1-4.0 μg/mL; 2 h) concentration-dependently inhibits LPS-induced TNF-α production in human peripheral blood monocytes with an IC50 of 4.0 μg/mL[1].
Trichodimerol (BMS-182123) (concentrations leading to full inhibition; 18-20 h) concentration-dependently inhibits LPS-induced human TNF-α promoter activity in transfected murine RAW macrophages with an IC50 of 200 ng/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Murine macrophages
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Concentration:2 μg/mL
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Incubation Time:4 h
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Result:Significantly reduced LPS-induced steady-state TNF-α mRNA expression in murine macrophages without altering mRNA stability.
Chemical Information
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CAS No. 145174-90-9
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Molecular Weight 496.55
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Formula C28H32O8
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SMILES
C[C@@]12[C@@]3([H])[C@]4([C@@](O1)([C@]5(O[C@@]2([C@@](C(O)=C3C(/C=C/C=C/C)=O)([C@@]5([H])C(C(/C=C/C=C/C)=O)=C4O)C)O)C)O)C
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Synonyms
BMS-182123
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Trichodimerol Related Classifications
HY-N12104 Related Classifications
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