Trichodimerol  (Synonyms: BMS-182123)

Trichodimerol (BMS-182123) is a TNF-α promoter inhibitor that inhibits the activity of lipopolysaccharide-induced cytokine secretion. Trichodimerol inhibits lipopolysaccharide-induced TNF-α promoter activity, reduces steady-state TNF-α mRNA expression, and does not alter the stability of TNF-α mRNA. Trichodimerol inhibits lipopolysaccharide-induced TNF-α secretion in murine and human immune cells. Trichodimerol reduces lipopolysaccharide-induced IL-1β secretion by 25%-50% in vitro. Trichodimerol does not alter total protein synthesis or constitutive lysozyme secretion at effective concentrations. Trichodimerol can be used for the research of septic shock^[1].

Trichodimerol (BMS-182123) (concentrations leading to >99% inhibition; ~20 h) concentration-dependently inhibits LPS-induced TNF-α production in murine RAW 264.7 macrophages with an IC₅₀ of 600 ng/mL^[1].
Trichodimerol (BMS-182123) (0.1-4.0 μg/mL; 2 h) concentration-dependently inhibits LPS-induced TNF-α production in human peripheral blood monocytes with an IC₅₀ of 4.0 μg/mL^[1].
Trichodimerol (BMS-182123) (concentrations leading to full inhibition; 18-20 h) concentration-dependently inhibits LPS-induced human TNF-α promoter activity in transfected murine RAW macrophages with an IC₅₀ of 200 ng/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

496.55

C₂₈H₃₂O₈

145174-90-9

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• [1]. Warr GA, et al. BMS-182123, a fungal metabolite that inhibits the production of TNF-alpha by macrophages and monocytes. J Antibiot (Tokyo). 1996;49(3):234-240.