145174-90-9
Chemical Structure
Trichodimerol
Synonym(s): BMS-182123
- CAS No.: 145174-90-9
- Formula:C28H32O8
- Molecular Weight:496.55
IUPAC Name: (2E,2'E,4E,4'E)-1,1'-((2S,3R,4aS,5R,8R,8aR,9R,12R)-3,7,8a,11-tetrahydroxy-2,4a,8,12-tetramethyl-2,3,4a,5,8,8a-hexahydro-2,8,3,5-(epibut[2]ene[1,1,4,4]tetrayl)benzo[b][1,4]dioxine-6,10-diyl)bis(hexa-2,4-dien-1-one)
InChIKey: VATYWOIGKMMCMM-OXGNLDDNSA-N
SMILES: C[C@@]12[C@@]3([H])[C@]4([C@@](O1)([C@]5(O[C@@]2([C@@](C(O)=C3C(/C=C/C=C/C)=O)([C@@]5([H])C(C(/C=C/C=C/C)=O)=C4O)C)O)C)O)C
Biological Activity: Trichodimerol (BMS-182123) is a TNF-α promoter inhibitor that inhibits the activity of lipopolysaccharide-induced cytokine secretion. Trichodimerol inhibits lipopolysaccharide-induced TNF-α promoter activity, reduces steady-state TNF-α mRNA expression, and does not alter the stability of TNF-α mRNA. Trichodimerol inhibits lipopolysaccharide-induced TNF-α secretion in murine and human immune cells. Trichodimerol reduces lipopolysaccharide-induced IL-1β secretion by 25%-50% in vitro. Trichodimerol does not alter total protein synthesis or constitutive lysozyme secretion at effective concentrations. Trichodimerol can be used for the research of septic shock[1].
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Trichodimerol | Trichodimerol (BMS-182123) is a TNF-α promoter inhibitor that inhibits the activity of lipopolysaccharide-induced cytokine secretion. Trichodimerol inhibits lipopolysaccharide-induced TNF-α promoter activity, reduces steady-state TNF-α mRNA expression, and does not alter the stability of TNF-α mRNA. Trichodimerol inhibits lipopolysaccharide-induced TNF-α secretion in murine and human immune cells. Trichodimerol reduces lipopolysaccharide-induced IL-1β secretion by 25%-50% in vitro. Trichodimerol does not alter total protein synthesis or constitutive lysozyme secretion at effective concentrations. Trichodimerol can be used for the research of septic shock. | |||||||||||||||||||||
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