2. MAPK/ERK Pathway Apoptosis Immunology/Inflammation
  3. p38 MAPK TNF Receptor Interleukin Related
  4. AS1940477

AS1940477 (Compound 3f) is an orally active p38 MAPK inhibitor. AS1940477 inhibits the enzymatic activity of recombinant p38α and β isoforms. AS1940477 inhibits the production of pro-inflammatory cytokines (including TNFα, IL-1β, and IL-6) in human synovial interstitial cells and animal models of inflammation. AS1940477 can be used in research on inflammatory diseases.

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AS1940477

AS1940477 Chemical Structure

CAS No. : 928344-12-1

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AS1940477 Related Antibodies

Top Publications Citing Use of Products

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p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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Description

AS1940477 (Compound 3f) is an orally active p38 MAPK inhibitor. AS1940477 inhibits the enzymatic activity of recombinant p38α and β isoforms. AS1940477 inhibits the production of pro-inflammatory cytokines (including TNFα, IL-1β, and IL-6) in human synovial interstitial cells and animal models of inflammation. AS1940477 can be used in research on inflammatory diseases[1][2].

Cellular Effect
Cell Line Type Value Description References
THP-1 IC50
0.6 nM
Compound: 3f, AS1940477
Antiinflammatory activity in human THP1 cells assessed as inhibition of LPS-induced TNFalpha production after 20 hrs
Antiinflammatory activity in human THP1 cells assessed as inhibition of LPS-induced TNFalpha production after 20 hrs
[PMID: 22905713]
Molecular Weight

431.46

Formula

C24H22FN5O2
CAS No.
SMILES

OC[C@H]1CN2C(NC1)=C(C3=NN(C4=C(C=CC=C4)C)C(C=C3)=O)C(C5=CC=C(C=C5)F)=N2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AS1940477 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AS1940477928344-12-1AS 1940477AS-1940477p38 MAPKTNF ReceptorInterleukin RelatedTumor Necrosis Factor ReceptorTNFRILInhibitorinhibitorinhibit

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