AS1940477
AS1940477 (Compound 3f) is an orally active p38 MAPK inhibitor. AS1940477 inhibits the enzymatic activity of recombinant p38α and β isoforms. AS1940477 inhibits the production of pro-inflammatory cytokines (including TNFα, IL-1β, and IL-6) in human synovial interstitial cells and animal models of inflammation. AS1940477 can be used in research on inflammatory diseases.
For research use only. We do not sell to patients.
- CAS No.: 928344-12-1
- Formula: C24H22FN5O2
- Molecular Weight:431.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| THP-1 | IC50 |
0.6 nM
Compound: 3f, AS1940477
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Antiinflammatory activity in human THP1 cells assessed as inhibition of LPS-induced TNFalpha production after 20 hrs
Antiinflammatory activity in human THP1 cells assessed as inhibition of LPS-induced TNFalpha production after 20 hrs
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[PMID: 22905713] |
Chemical Information
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CAS No. 928344-12-1
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Molecular Weight 431.46
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Formula C24H22FN5O2
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SMILES
OC[C@H]1CN2C(NC1)=C(C3=NN(C4=C(C=CC=C4)C)C(C=C3)=O)C(C5=CC=C(C=C5)F)=N2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Asano T, Yet al. Identification, synthesis, and biological evaluation of 6-[(6R)-2-(4-fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2H)-one (AS1940477), a potent p38 MAP kinase inhibitor. J Med Chem. 2012 Sep 13;55(17):7772-85. [Content Brief]
[2]. Terajima M, et al. Anti-inflammatory effect and selectivity profile of AS1940477, a novel and potent p38 mitogen-activated protein kinase inhibitor. Eur J Pharmacol. 2013 Jan 5;698(1-3):455-62. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AS1940477 Related Classifications
HY-13478 Related Classifications
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