928344-12-1
Chemical Structure
AS1940477
- CAS No.: 928344-12-1
- Formula:C24H22FN5O2
- Molecular Weight:431.46
IUPAC Name: (R)-6-(2-(4-fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl)-2-(o-tolyl)pyridazin-3(2H)-one
InChIKey: LYHNSWOZRDSWLX-MRXNPFEDSA-N
SMILES: OC[C@H]1CN2C(NC1)=C(C3=NN(C4=C(C=CC=C4)C)C(C=C3)=O)C(C5=CC=C(C=C5)F)=N2
Biological Activity: AS1940477 (Compound 3f) is an orally active p38 MAPK inhibitor. AS1940477 inhibits the enzymatic activity of recombinant p38α and β isoforms. AS1940477 inhibits the production of pro-inflammatory cytokines (including TNFα, IL-1β, and IL-6) in human synovial interstitial cells and animal models of inflammation. AS1940477 can be used in research on inflammatory diseases[1][2].
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AS1940477 | AS1940477 (Compound 3f) is an orally active p38 MAPK inhibitor. AS1940477 inhibits the enzymatic activity of recombinant p38α and β isoforms. AS1940477 inhibits the production of pro-inflammatory cytokines (including TNFα, IL-1β, and IL-6) in human synovial interstitial cells and animal models of inflammation. AS1940477 can be used in research on inflammatory diseases. | |||||||||||||||||||||
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- [1]. Asano T, Yet al. Identification, synthesis, and biological evaluation of 6-[(6R)-2-(4-fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2H)-one (AS1940477), a potent p38 MAP kinase inhibitor. J Med Chem. 2012 Sep 13;55(17):7772-85. [Content Brief]
- [2]. Terajima M, et al. Anti-inflammatory effect and selectivity profile of AS1940477, a novel and potent p38 mitogen-activated protein kinase inhibitor. Eur J Pharmacol. 2013 Jan 5;698(1-3):455-62. [Content Brief]
Keywords
