2. Apoptosis
  3. TNF Receptor
  4. (20S)-18,20-Epoxydigitoxigenin α-L-thvetoside

(20S)-18,20-Epoxydigitoxigenin α-L-thvetoside is a cardenolide glycoside found in the bark of Thevetia peruviana. (20S)-18,20-Epoxydigitoxigenin α-L-thvetoside is a tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) resistance-overcoming agent. (20S)-18,20-Epoxydigitoxigenin α-L-thvetoside synergistically sensitizes TRAIL-resistant gastric adenocarcinoma cells to TRAIL, reducing cell viability when combined with TRAIL. (20S)-18,20-Epoxydigitoxigenin α-L-thvetoside can be used for the research of human gastric adenocarcinoma.

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(20S)-18,20-Epoxydigitoxigenin α-L-thvetoside

(20S)-18,20-Epoxydigitoxigenin α-L-thvetoside 화학구조

CAS No. : 71129-71-0

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(20S)-18,20-Epoxydigitoxigenin α-L-thvetoside Related Antibodies

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제품 설명

(20S)-18,20-Epoxydigitoxigenin α-L-thvetoside is a cardenolide glycoside found in the bark of Thevetia peruviana. (20S)-18,20-Epoxydigitoxigenin α-L-thvetoside is a tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) resistance-overcoming agent. (20S)-18,20-Epoxydigitoxigenin α-L-thvetoside synergistically sensitizes TRAIL-resistant gastric adenocarcinoma cells to TRAIL, reducing cell viability when combined with TRAIL. (20S)-18,20-Epoxydigitoxigenin α-L-thvetoside can be used for the research of human gastric adenocarcinoma[1].

In Vitro

(20S)-18,20-Epoxydigitoxigenin α-L-thvetoside (Compound 4) (114-909 nM; 24 h) synergistically overcomes tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), resistance in human gastric adenocarcinoma AGS cells, with the most potent effect observed at 909 nM combined with 100 ng/mL TRAIL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(20S)-18,20-Epoxydigitoxigenin α-L-thvetoside Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: TRAIL-resistant human gastric adenocarcinoma AGS cells
Concentration: 114 nM, 227 nM, 455 nM, 909 nM
Incubation Time: 24 h
Result: Reduced cell viability when combined with 100 ng/mL TRAIL compared to treatment with the reagent alone.
Reduced cell viability to near 0% at 909 nM combined with 100 ng/mL TRAIL, while viability with the reagent alone was approximately 30%.
분자량

550.68

화학식

C30H46O9
CAS No.
SMILES

O[C@@]12[C@]3(CC[C@@]4([H])[C@@]2([H])CC[C@@]5([H])[C@@]4(CC[C@@H](C5)O[C@H]6[C@H]([C@@H]([C@H]([C@@H](O6)C)O)OC)O)C)[C@@](CC1)([H])[C@@]7(CC(OC7)=O)OC3
Structure Classification
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

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(20S)-18,20-Epoxydigitoxigenin α-L-thvetoside Related Classifications

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Keywords:

(20S)-18,20-Epoxydigitoxigenin α-L-thvetoside71129-71-0TNF ReceptorTumor Necrosis Factor ReceptorTNFRAGS cellsThevetia peruvianahuman gastric adenocarcinomagastric adenocarcinoma cellsTRAIL resistanceInhibitorinhibitorinhibit

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(20S)-18,20-Epoxydigitoxigenin α-L-thvetoside
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HY-N19640
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