(20S)-18,20-Epoxydigitoxigenin α-L-thvetoside
(20S)-18,20-Epoxydigitoxigenin α-L-thvetoside is a cardenolide glycoside found in the bark of Thevetia peruviana. (20S)-18,20-Epoxydigitoxigenin α-L-thvetoside is a tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) resistance-overcoming agent. (20S)-18,20-Epoxydigitoxigenin α-L-thvetoside synergistically sensitizes TRAIL-resistant gastric adenocarcinoma cells to TRAIL, reducing cell viability when combined with TRAIL. (20S)-18,20-Epoxydigitoxigenin α-L-thvetoside can be used for the research of human gastric adenocarcinoma.
For research use only. We do not sell to patients.
- CAS No.: 71129-71-0
- Formula: C30H46O9
- Molecular Weight:550.68
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
In Vitro
(20S)-18,20-Epoxydigitoxigenin α-L-thvetoside (Compound 4) (114-909 nM; 24 h) synergistically overcomes tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), resistance in human gastric adenocarcinoma AGS cells, with the most potent effect observed at 909 nM combined with 100 ng/mL TRAIL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:TRAIL-resistant human gastric adenocarcinoma AGS cells
-
Concentration:114 nM, 227 nM, 455 nM, 909 nM
-
Incubation Time:24 h
-
Result:Reduced cell viability when combined with 100 ng/mL TRAIL compared to treatment with the reagent alone.
Reduced cell viability to near 0% at 909 nM combined with 100 ng/mL TRAIL, while viability with the reagent alone was approximately 30%.
Chemical Information
-
CAS No. 71129-71-0
-
Molecular Weight 550.68
-
Formula C30H46O9
-
SMILES
O[C@@]12[C@]3(CC[C@@]4([H])[C@@]2([H])CC[C@@]5([H])[C@@]4(CC[C@@H](C5)O[C@H]6[C@H]([C@@H]([C@H]([C@@H](O6)C)O)OC)O)C)[C@@](CC1)([H])[C@@]7(CC(OC7)=O)OC3
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(20S)-18,20-Epoxydigitoxigenin α-L-thvetoside Related Classifications
HY-N19640 Related Classifications
Powered by Bioz