Anticancer agent 331
Anticancer agent 331 is an anticancer agent with favorable cell permeability and limited blood-brain barrier penetration. Anticancer agent 331 forms stable long-acting complexes with TNF-α, PI3K p110α, AKT1 and mTOR, and exerts cytotoxic effects on cancer cells. Anticancer agent 331 can be used in the research of colorectal cancer.
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- Formule: C29H20ClN5O3S2
- Masse moléculaire:586.08
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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Akt1 |
p110α |
Anticancer agent 331 (compound 5d) (4.10-49.08 µM) potently inhibits human colorectal carcinoma HCT-116 cell viability with an IC50 of 4.10 µM and exhibits high selectivity for cancer cells over human dermal fibroblast CCD-1076Sk cells, with a selectivity index of 12.0[1].
Anticancer agent 331 has a viable pharmacokinetic profile, with acceptable intestinal permeability, good predicted oral absorption, limited blood-brain barrier penetration, and two Lipinski rule of five violations typical of potent kinase inhibitors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 586.08
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Formule C29H20ClN5O3S2
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SMILES
O=S(C1=CN=CC=C1)(N2C=C(C3=CC=CC=C32)/C=N/N=C4SC=C(N\4C5=CC=CC(Cl)=C5)C6=CC=C(C=C6)O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent 331 Related Classifications
HY-184487 Related Classifications
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