Enniatin B1
Based on 1 publication(s) in Google Scholar
Enniatin B1 is a Fusarium mycotoxin. Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 73 μM in an enzyme assay using rat liver microsomes. Enniatin B1 crosss the blood-brain barrier. Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation.
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- Pureza: 99.33%
- No. CAS: 19914-20-6
- Fòrmula: C34H59N3O9
- Peso molecular:653.85
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Almacenamiento:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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HY-125539
Roridin E -
HY-107426
Verrucarin A -
HY-130476
Satratoxin G -
HY-19696A
Tauroursodeoxycholate sodium -
HY-N3806
Enniatin B -
HY-19696AR
Tauroursodeoxycholate sodium (Standard) -
HY-N0590
Corynoxeine -
HY-114936
Piericidin A -
HY-N6706
Enniatin complex -
HY-N6702
Enniatin A -
HY-N6704
Enniatin A1 -
HY-N0590R
Corynoxeine (Standard)
Publications Citing Use of MedChemExpress (MCE) Enniatin B1
More
Actividad biológica
Descripciòn
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ACAT |
ERK |
NF-κB |
In Vitro
CCF-STTG1 cells are sensitive to Enniatin B1 (IC50=4.4 μM)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 19914-20-6
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Appearance Solid
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Peso molecular 653.85
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Fòrmula C34H59N3O9
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Color White to off-white
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SMILES
CC[C@@H]([C@]1([H])N(C([C@H](OC([C@](N(C([C@@H](C(C)C)OC([C@H](C(C)C)N(C)C([C@](C(C)C)([H])OC1=O)=O)=O)=O)C)([H])C(C)C)=O)C(C)C)=O)C)C
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Structure Classification
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Initial Source
Fusarium mycotoxins
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Ecotoxicol Environ Saf
Enniatin B1 induces damage to Leydig cells via inhibition of the Nrf2/HO-1 and JAK/STAT3 signaling pathways. [Abstract]2024 Mar 15:273:116116. PMID: 38387140
Solvente y solubilidad
In Vitro:
DMSO : ≥ 10 mg/mL (15.29 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (280 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Tomoda H, et al. Inhibition of acyl-CoA: cholesterol acyltransferase activity by cyclodepsipeptide antibiotics. J Antibiot (Tokyo). 1992 Oct;45(10):1626-32. [Content Brief]
[2]. Krug I, et al. Transport of enniatin B and enniatin B1 across the blood-brain barrier and hints for neurotoxic effects in cerebral cells. PLoS One. 2018 May 16;13(5):e0197406. [Content Brief]
[3]. Wätjen W, et al. Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation. Mol Nutr Food Res. 2009 Apr;53(4):431-40. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5294 mL | 7.6470 mL | 15.2940 mL | 38.2351 mL |
| 5 mM | 0.3059 mL | 1.5294 mL | 3.0588 mL | 7.6470 mL | |
| 10 mM | 0.1529 mL | 0.7647 mL | 1.5294 mL | 3.8235 mL | |
| 15 mM | 0.1020 mL | 0.5098 mL | 1.0196 mL | 2.5490 mL |
Enniatin B1 Related Classifications
HY-N3807 Related Classifications
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