Cat. No.: HY-164102

TNF-α-IN-18

Customer Review

Based on 1 Customer Validation

TNF-α-IN-18 (Compound 61) is an inhibitor for TNF-α (IC₅₀ of 1.8 μM), that inhibits TNF signaling pathway through block of NF-kB migration from cytoplasm to nucleus. TNF-α-IN-18 exhibits slight cytotoxicity to mouse fibroblast LM cell, with a CC₅₀ >50 μM. TNF-α-IN-18 ameliorates the TNF- or Lipopolysaccharide (HY-D1056)-induced sepsis in mouse models. TNF-α-IN-18 protects mice from rheumatoid arthritis.

For research use only. We do not sell to patients.

Purity: 98.94%
CAS No.: 1272322-42-5
Formula: C₁₆H₇ClF₂O₄
Molecular Weight:336.67

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

TNF-α-IN-18 Chemical Structure

CAS No.: 1272322-42-5

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Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All TNF Receptor Isoforms :

All NF-κB Isoforms :

Chemical Information

CAS No. 1272322-42-5
Appearance Solid
Molecular Weight 336.67
Formula C₁₆H₇ClF₂O₄
Color White to off-white
SMILES

O=C(C1=C(C2=C(F)C=CC(F)=C2)OC3=CC(Cl)=CC=C3C1=O)O
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (297.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.9703 mL

14.8513 mL

29.7027 mL

5 mM

0.5941 mL

2.9703 mL

5.9405 mL

10 mM

0.2970 mL

1.4851 mL

2.9703 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Heo T, et al., Composition for preventing or treating tnf-related diseases, containing novel derivative as active ingredient, and method for inhibiting tnf activity by using same. WO2019078452 A1.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.9703 mL	14.8513 mL	29.7027 mL	74.2567 mL
	5 mM	0.5941 mL	2.9703 mL	5.9405 mL	14.8513 mL
	10 mM	0.2970 mL	1.4851 mL	2.9703 mL	7.4257 mL
	15 mM	0.1980 mL	0.9901 mL	1.9802 mL	4.9504 mL
	20 mM	0.1485 mL	0.7426 mL	1.4851 mL	3.7128 mL
	25 mM	0.1188 mL	0.5941 mL	1.1881 mL	2.9703 mL
	30 mM	0.0990 mL	0.4950 mL	0.9901 mL	2.4752 mL
	40 mM	0.0743 mL	0.3713 mL	0.7426 mL	1.8564 mL
	50 mM	0.0594 mL	0.2970 mL	0.5941 mL	1.4851 mL
	60 mM	0.0495 mL	0.2475 mL	0.4950 mL	1.2376 mL
	80 mM	0.0371 mL	0.1856 mL	0.3713 mL	0.9282 mL
	100 mM	0.0297 mL	0.1485 mL	0.2970 mL	0.7426 mL

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TNF-α-IN-18

Apoptosis Compound Library

Immunology/Inflammation Compound Library

NF-κB Signaling Compound Library

Stem Cell Signaling Compound Library

Anti-Aging Compound Library

Antioxidant Compound Library

Differentiation Inducing Compound Library

Oxygen Sensing Compound Library

Pyroptosis Compound Library

Anti-Breast Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Anti-Obesity Compound Library

Angiogenesis-Related Compound Library

Transcription Factor-Targeted Library

Anti-Liver Cancer Compound Library

Antidepressant Compound Library

Anti-Prostate Cancer Compound Library

Anti-Pulmonary Fibrosis Compound Library

Cancer Stem Cells Compound Library

Pain-Related Compound Library

Mitochondrial Protection Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Autoimmune Disease Compound Library

Cytokine Inhibitors Library

Anti-Hematopathy Compound Library

Anti-Ovarian Cancer Compound Library

Multi-Target Compound Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Anti-Fibrosis Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Anti-Rheumatic Arthritis Compound Library

Lactylation Compound Library

All TNF Receptor Isoforms

All NF-κB Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

TNF-α-IN-18 Related Classifications

Cat. No.: HY-164102