TNF-α-IN-18
Based on 1 Customer Validation
TNF-α-IN-18 (Compound 61) is an inhibitor for TNF-α (IC50 of 1.8 μM), that inhibits TNF signaling pathway through block of NF-kB migration from cytoplasm to nucleus. TNF-α-IN-18 exhibits slight cytotoxicity to mouse fibroblast LM cell, with a CC50 >50 μM. TNF-α-IN-18 ameliorates the TNF- or Lipopolysaccharide (HY-D1056)-induced sepsis in mouse models. TNF-α-IN-18 protects mice from rheumatoid arthritis.
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- Pureté : 98.94%
- CAS No.: 1272322-42-5
- Formule: C16H7ClF2O4
- Masse moléculaire:336.67
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
Chemical Information
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CAS No. 1272322-42-5
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Appearance Solid
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Masse moléculaire 336.67
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Formule C16H7ClF2O4
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Color White to off-white
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SMILES
O=C(C1=C(C2=C(F)C=CC(F)=C2)OC3=CC(Cl)=CC=C3C1=O)O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : 100 mg/mL (297.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Pureté et documentation
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Fiche technique (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9703 mL | 14.8513 mL | 29.7027 mL | 74.2567 mL |
| 5 mM | 0.5941 mL | 2.9703 mL | 5.9405 mL | 14.8513 mL | |
| 10 mM | 0.2970 mL | 1.4851 mL | 2.9703 mL | 7.4257 mL | |
| 15 mM | 0.1980 mL | 0.9901 mL | 1.9802 mL | 4.9504 mL | |
| 20 mM | 0.1485 mL | 0.7426 mL | 1.4851 mL | 3.7128 mL | |
| 25 mM | 0.1188 mL | 0.5941 mL | 1.1881 mL | 2.9703 mL | |
| 30 mM | 0.0990 mL | 0.4950 mL | 0.9901 mL | 2.4752 mL | |
| 40 mM | 0.0743 mL | 0.3713 mL | 0.7426 mL | 1.8564 mL | |
| 50 mM | 0.0594 mL | 0.2970 mL | 0.5941 mL | 1.4851 mL | |
| 60 mM | 0.0495 mL | 0.2475 mL | 0.4950 mL | 1.2376 mL | |
| 80 mM | 0.0371 mL | 0.1856 mL | 0.3713 mL | 0.9282 mL | |
| 100 mM | 0.0297 mL | 0.1485 mL | 0.2970 mL | 0.7426 mL |
TNF-α-IN-18 Related Classifications
HY-164102 Related Classifications
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