1. MAPK/ERK Pathway
  2. p38 MAPK
  3. FR 167653 free base

FR 167653 free base 

Cat. No.: HY-18754
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FR 167653 free base, an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity. FR 167653 free base is effective in treating inflammation, relieving trauma and ischemia-reperfusion injury in vivo.

For research use only. We do not sell to patients.

FR 167653 free base Chemical Structure

FR 167653 free base Chemical Structure

CAS No. : 158876-65-4

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Description

FR 167653 free base, an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity. FR 167653 free base is effective in treating inflammation, relieving trauma and ischemia-reperfusion injury in vivo[1][2][3].

In Vivo

FR 167653 free base (32 mg/kg; i.h.; 24-48 hours) significantly decreases the extent of acute tubular necrosis[1].

Animal Model: Inbred male Balbuc mice (aged 8 weeks)[1]
Dosage: 32 mg/kg
Administration: Subcutaneous injection; 24-48 hours
Result: The scores of acute tubular necrosis in FR-167653-treated mice were significantly lower in vehicle-treated mice at 24 and 48 h after ischaemiaureperfusion both in cortex and outer medulla.
Molecular Weight

427.43

Formula

C₂₄H₁₈FN₅O₂

CAS No.

158876-65-4

SMILES

O=C(N1NC2=C(C3=CC=NC=C3)C(C4=CC=C(F)C=C4)=NN2CC1)C(C5=CC=CC=C5)=O

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FR 167653 free base
Cat. No.:
HY-18754
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