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Antitumor agent-19 is an antitomor agent targeting tumor-associated macrophages (TAMs) to serve as an effective TAMs modulator. The EC50 values of Antitumor agent-19 in the RAW 264.7 cells and the BMDM cells are 17.18 μM and 18.87 μM, respectively.

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Antitumor agent-19 Chemical Structure

Antitumor agent-19 Chemical Structure

CAS No. : 2379727-90-7

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Description

Antitumor agent-19 is an antitomor agent targeting tumor-associated macrophages (TAMs) to serve as an effective TAMs modulator. The EC50 values of Antitumor agent-19 in the RAW 264.7 cells and the BMDM cells are 17.18 μM and 18.87 μM, respectively[1].

IC50 & Target

tumor-associated macrophages (TAMs)[1]

In Vitro

Antitumor agent-19 (Compound 23a; 10-50 µM; 1 hour; RAW 264.7 cells) treatment effectively induces the expression of M1-phenotype macrophage markers (IL-1β, TNF-α, iNOS and IL-12α) in a dose-dependent manner. Antitumor agent-19 is found to dose-dependently repolarize TAMs from M1 (anti-tumor) and M2 (pro-tumor)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[1]

Cell Line: RAW 264.7 cells
Concentration: 10 µM, 20 µM, or 50 µM
Incubation Time: 1 hour
Result: Induced the expression of M1-phenotype macrophage markers (IL-1β, TNF-α, iNOS and IL-12α) in a dose-dependent manner.
In Vivo

Antitumor agent-19 (Compound 23a; 5 mg/kg; intraperitoneal injection; every other day; for 30 days; C57BL/6 female mice) is capable of remarkably inhibiting tumor growth of the LLC mouse model. Moreover, the synergy of Antitumor agent-19 with anti-PD-1 antibody has more superior antineoplastic effects than the exclusive use of either in vivo[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six-to eight-week-old C57BL/6 female mice with lewis lung cancer cells (LLC)[1]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection; every other day; for 30 days
Result: Remarkably inhibited tumor growth of the LLC mouse model.
Molecular Weight

487.90

Formula

C24H21ClF3N5O

CAS No.
SMILES

O=C(NC1CCC(NC2=C3C(C4=CN(C)N=C4)=CC=C2)=C3C1)NC5=CC=C(Cl)C(C(F)(F)F)=C5

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Antitumor agent-19 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Antitumor agent-19
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HY-128776
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