Antitumor agent-19
Antitumor agent-19 is an antitumor agent that targets tumor-associated macrophages (TAMs) and can be used as a potent TAMs modulator. Antitumor agent-19 can increase TNF-alpha levels in tumor cells with EC50 values???of 17.18 μM and 18.87 μM in RAW 264.7 cells and BMDM cells, respectively.
For research use only. We do not sell to patients.
- CAS No.: 2379727-90-7
- Formula: C24H21ClF3N5O
- Molecular Weight:487.90
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Help & FAQs
Biological Activity
tumor-associated macrophages (TAMs)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BMDM | EC50 |
18.87 μM
Compound: 23a
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Increase in TNF-alpha production in mouse BMDM cells incubated for 24 hrs by ELISA
Increase in TNF-alpha production in mouse BMDM cells incubated for 24 hrs by ELISA
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[PMID: 31605873] |
| RAW264.7 | EC50 |
17.18 μM
Compound: 23a
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Increase in TNF-alpha production in mouse RAW264.7 cells incubated for 24 hrs by ELISA
Increase in TNF-alpha production in mouse RAW264.7 cells incubated for 24 hrs by ELISA
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[PMID: 31605873] |
Antitumor agent-19 (Compound 23a; 10-50 μM; 1 hour; RAW 264.7 cells) treatment effectively induces the expression of M1-phenotype macrophage markers (IL-1β, TNF-α, iNOS and IL-12α) in a dose-dependent manner. Antitumor agent-19 is found to dose-dependently repolarize TAMs from M1 (anti-tumor) and M2 (pro-tumor)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW 264.7 cells
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Concentration:10 µM, 20 µM, or 50 µM
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Incubation Time:1 hour
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Result:Induced the expression of M1-phenotype macrophage markers (IL-1β, TNF-α, iNOS and IL-12α) in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Six-to eight-week-old C57BL/6 female mice with lewis lung cancer cells (LLC)[1]
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Dosage:5 mg/kg
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Administration:Intraperitoneal injection; every other day; for 30 days
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Result:Remarkably inhibited tumor growth of the LLC mouse model.
Chemical Information
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CAS No. 2379727-90-7
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Molecular Weight 487.90
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Formula C24H21ClF3N5O
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SMILES
O=C(NC1CCC(NC2=C3C(C4=CN(C)N=C4)=CC=C2)=C3C1)NC5=CC=C(Cl)C(C(F)(F)F)=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitumor agent-19 Related Classifications
HY-128776 Related Classifications
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