2379727-90-7
2379727-90-7
Chemical Structure
Antitumor agent-19
- CAS No.: 2379727-90-7
- Formula:C24H21ClF3N5O
- Molecular Weight:487.90
IUPAC Name: 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(5-(1-methyl-1H-pyrazol-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl)urea
InChIKey: RTILPKXOEYEQSE-UHFFFAOYSA-N
SMILES: O=C(NC1CCC(NC2=C3C(C4=CN(C)N=C4)=CC=C2)=C3C1)NC5=CC=C(Cl)C(C(F)(F)F)=C5
Biological Activity: Antitumor agent-19 is an antitumor agent that targets tumor-associated macrophages (TAMs) and can be used as a potent TAMs modulator. Antitumor agent-19 can increase TNF-alpha levels in tumor cells with EC50 values???of 17.18 μM and 18.87 μM in RAW 264.7 cells and BMDM cells, respectively[1].
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Antitumor agent-19 | Antitumor agent-19 is an antitumor agent that targets tumor-associated macrophages (TAMs) and can be used as a potent TAMs modulator. Antitumor agent-19 can increase TNF-alpha levels in tumor cells with EC50 values???of 17.18 μM and 18.87 μM in RAW 264.7 cells and BMDM cells, respectively. | |||||||||||||||||||||
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