Anti-inflammatory agent 111
Anti-inflammatory agent 111 is a potent anti-inflammatory agent. Anti-inflammatory agent 111 reduces Lipopolysaccharides (LPS) (HY-D1056)-induced i-NOS and COX-2 protein expression, decreases nitric oxide, IL-6, and TNF-α production. Anti-inflammatory agent 111 maintains normal cell viability at bioactive concentrations.Anti-inflammatory agent 111 can be used for the research of inflammation-related disorders.
For research use only. We do not sell to patients.
- Formula: C24H28N4O3
- Molecular Weight:420.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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COX-2 |
iNOS |
IL-6 |
TNF-α |
Anti-inflammatory agent 111 (compound 3d) (1-10 μM; 48 h) maintains greater than 90% cell viability in RAW264.7 macrophages when treated at 1, 5, or 10 μM for 48 h[1].
Anti-inflammatory agent 111 (1-10 μM; 1 h pre-treatment, 24 h LPS stimulation) inhibits LPS-induced NO production in RAW264.7 macrophages with 50.5% inhibition at 10 μM, 28.3% at 5 μM, and 14.5% at 1 μM[1].
Anti-inflammatory agent 111 (1-10 μM; 1 h pre-treatment, 24 h LPS stimulation) significantly reduces LPS-induced IL-6 and TNF-α release in RAW264.7 macrophages in vitro in a concentration-dependent manner[1].
Anti-inflammatory agent 111 (5-10 μM; 1 h pre-treatment, 24 h LPS stimulation) suppresses LPS-induced i-NOS and COX-2 protein expression in RAW264.7 macrophages[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW264.7 macrophages
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Concentration:1, 5, 10 μM
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Incubation Time:48 h
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Result:Maintained cell viability greater than 90% at all tested concentrations.
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Cell Line:LPS-stimulated RAW264.7 macrophages
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Concentration:5, 10 μM
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Incubation Time:1 h (pre-treatment); 24 h (LPS stimulation)
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Result:Suppressed the LPS-induced increase in i-NOS and COX-2 protein expression.
Chemical Information
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Molecular Weight 420.50
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Formula C24H28N4O3
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SMILES
O=C(OCC)CCNC1=C(N(C)C)N=C(C2=CC=CC=C2)N(C3=CC=CC=C3C)C1=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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