Anti-inflammatory agent 111 

Anti-inflammatory agent 111 is a potent anti-inflammatory agent. Anti-inflammatory agent 111 reduces Lipopolysaccharides (LPS) (HY-D1056)-induced i-NOS and COX-2 protein expression, decreases nitric oxide, IL-6, and TNF-α production. Anti-inflammatory agent 111 maintains normal cell viability at bioactive concentrations.Anti-inflammatory agent 111 can be used for the research of inflammation-related disorders^[1].

Anti-inflammatory agent 111 (compound 3d) (1-10 μM; 48 h) maintains greater than 90% cell viability in RAW264.7 macrophages when treated at 1, 5, or 10 μM for 48 h^[1].
Anti-inflammatory agent 111 (1-10 μM; 1 h pre-treatment, 24 h LPS stimulation) inhibits LPS-induced NO production in RAW264.7 macrophages with 50.5% inhibition at 10 μM, 28.3% at 5 μM, and 14.5% at 1 μM^[1].
Anti-inflammatory agent 111 (1-10 μM; 1 h pre-treatment, 24 h LPS stimulation) significantly reduces LPS-induced IL-6 and TNF-α release in RAW264.7 macrophages in vitro in a concentration-dependent manner^[1].
Anti-inflammatory agent 111 (5-10 μM; 1 h pre-treatment, 24 h LPS stimulation) suppresses LPS-induced i-NOS and COX-2 protein expression in RAW264.7 macrophages^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

420.50

C₂₄H₂₈N₄O₃

O=C(OCC)CCNC1=C(N(C)C)N=C(C2=CC=CC=C2)N(C3=CC=CC=C3C)C1=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Naikoo RA, et al. Design, Synthesis, and Anti-Inflammatory Activity of Functionalized 1,2,4,5-Tetrasubstituted-Pyrimidinone. Chem Biodivers. 2026;23(1):e02861.  [Content Brief]