NPSR1 antagonist-1
NPSR1 antagonist-1 is a potent and peripherally restricted neuropeptide S receptor 1 (NPSR1) antagonist. NPSR1 antagonist-1 can inhibit IL-6, PTGS2, IL-20, and CXCL8 expression. NPSR1 antagonist-1 can reduce TNF-α cytokine levels. NPSR1 antagonist-1 can be used for the research of inflammation, such as peritonitis.
For research use only. We do not sell to patients.
- CAS No.: 3113770-74-1
- Formula: C30H42F2N4O2
- Molecular Weight:528.68
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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IL-6 |
IL-20 |
TNF-α |
NPSR1 antagonist-1 (Compound 6) exhibits an IC50 of 0.35 nM and 0.15 nM against NPSR1-A and NPSR1-B, respectively[1].
NPSR1 antagonist-1 inhibits Npsr1 in HEK293T cells with an IC50 of 2.1 nM[1].
NPSR1 antagonist-1 (0.001-10000 nM, 30 mins) inhibits IL6, CXCL8, IL20, and PTGS2 levels in NPSR1-A expressing fibroblasts[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NPSR1-A expressing fibroblasts
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Concentration:0.001, 0.01, 0.1, 1, 10,100, 1000 and 10000 nM
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Incubation Time:30 mins
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Result:Reduced IL6, CXCL8, IL20, and PTGS2 levels.
NPSR1 antagonist-1 (40 mg/kg, i.p., before zymosan injection) reduces peritoneal levels of TNF-α in zymosan-induced peritonitis mice models[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Zymosan-induced peritonitis mice models[1]
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Dosage:10 mg/kg
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Administration:Intraperitoneally injection, before zymosan injection
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Result:Increased the number of F4/80+ resident macrophages in the peritoneum.
Chemical Information
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CAS No. 3113770-74-1
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Molecular Weight 528.68
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Formula C30H42F2N4O2
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SMILES
O=C(C1CCCCC1)N(CC2(N3CCN(C)CC3)CCC(F)(F)CC2)CC4=CC5=C(N(C)C4=O)C=CC=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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