BSF2 

BSF2 is a anti-Leishmania agent. BSF2 modulates gene expression linked to ubiquitination, chromatin remodeling, and peroxisomal membrane transport pathways in Leishmania braziliensis. BSF2 downregulates TNF, IL-17, NF-κB, and Toll-like receptor pathways in Leishmania-infected macrophages. BSF2 exerts leishmanicidal activity against intracellular Leishmania braziliensis amastigotes. BSF2 can be used for the research of american tegumentary leishmaniasis^[1].

BSF2 (1-80 μM; 48 h) exhibits a CC₅₀ of 11.11 μM against RAW 264.7 mouse macrophages, with 81.52% macrophage viability remaining at a 10 μM treatment concentration^[1].
BSF2 (1-80 μM; 48 h) potently inhibits intracellular Leishmania braziliensis in RAW 264.7 macrophages with an EC₅₀ of 0.64 μM and a high selectivity index of 17.36, reducing parasite viability to 5.73% at a 10 μM treatment concentration^[1].
BSF2 (0.16 μM; 48 h) alters parasite gene expression in ubiquitination, chromatin remodeling, and peroxisomal transport pathways, while downregulating host inflammatory pathways including TNF, IL-17, NF-κB, and Toll-like receptor signaling in Leishmania braziliensis-infected RAW 264.7 macrophages^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

332.40

C₂₀H₂₀N₄O

179118-06-0

CC1=C(OC(C2=CC=C(C=C2)C(N)=N)=C1C)C3=CC=C(C=C3)C(N)=N

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Agripino J, et al. Bisamidine Derivatives as Candidates for Tegumentary Leishmaniasis Therapy: Phenotypic Screening in Infection of Macrophages and Mechanistic Insights with Dual RNA-seq. ACS Omega. 2026;11(13):20270-20284. Published 2026 Mar 27.  [Content Brief]