4-Isopropylbenzyl alcohol
Based on 1 Customer Validation
4-Isopropylbenzyl alcohol (Cuminic alcohol) is an opioid-dependent analgesic. 4-Isopropylbenzyl alcohol activates opioid receptor, regulates the L-Arginine (HY-N0455)/NO/cGMP pathway, and reduces spinal cord TNF-α and IL-1β levels; it binds to BSA (HY-D0842) via static quenching. 4-Isopropylbenzyl alcohol can be used in research related to nociceptive pain, neuropathic pain, bacterial infection and diabetes.
For research use only. We do not sell to patients.
- Purity: 99.48%
- CAS No.: 536-60-7
- Formula: C10H14O
- Molecular Weight:150.22
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Opioid Receptor Isoforms
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Biological Activity
4-Isopropylbenzyl alcohol (6.25-25 mg/kg; i.p.; once daily; 14 days) dose-dependently relieves mechanical allodynia, cold allodynia, and thermal hyperalgesia, and reduces spinal inflammatory cytokine levels, in a rat chronic constriction injury model of neuropathic pain[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NMRI mice (male, 25-30 g)[1]
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Dosage:25 mg/kg; 50 mg/kg; 100 mg/kg; 200 mg/kg; 400 mg/kg
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Administration:i.p.; single dose
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Result:Prolonged hot plate latency significantly at 200 mg/kg and 400 mg/kg doses, with an ED50 of 65.23 mg/kg for this test; this effect was antagonized by naloxone.
Reduced paw licking time in the early phase of the formalin test at 50 mg/kg and 100 mg/kg doses, with an ED50 of 62.05 mg/kg for the early phase.
Reduced paw licking time in the late phase of the formalin test at 25 mg/kg, 50 mg/kg, and 100 mg/kg doses, with an ED50 of 43.46 mg/kg for the late phase.
Reduced acetic acid-induced writhing at 50 mg/kg and 100 mg/kg doses, with an ED50 of 41.63 mg/kg for this test.
Reversed antinociceptive effect of 50 mg/kg dose by L-arginine and sodium nitroprusside, potentiated by methylene blue, and unaffected by glibenclamide and tetraethylammonium chloride.
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Animal Model:Wistar rats (male, 220-250 g, chronic constriction injury model)[1]
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Dosage:6.25 mg/kg; 12.5 mg/kg; 25 mg/kg
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Administration:i.p.; once daily; 14 days
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Result:Increased paw withdrawal threshold in the mechanical allodynia test on days 7 and 14 post-injury at 6.25 mg/kg, 12.5 mg/kg, and 25 mg/kg doses.
Reduced paw withdrawal frequency in the cold allodynia test on days 7 and 14 post-injury at 12.5 mg/kg and 25 mg/kg doses.
Increased paw withdrawal latency in the thermal hyperalgesia test on days 7 and 14 post-injury at 12.5 mg/kg and 25 mg/kg doses, with the 25 mg/kg dose showing effects as early as day 3.
Reduced spinal cord levels of TNF-α and IL-1β on day 14 post-injury at 6.25 mg/kg, 12.5 mg/kg, and 25 mg/kg doses.
Chemical Information
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CAS No. 536-60-7
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Appearance Liquid (Density: 0.982 g/cm3)
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Molecular Weight 150.22
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Formula C10H14O
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Color Colorless to light yellow
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SMILES
OCC1=CC=C(C(C)C)C=C1
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Synonyms
Cuminic alcohol
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (665.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (16.64 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (16.64 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (282 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.6569 mL | 33.2845 mL | 66.5690 mL | 166.4226 mL |
| 5 mM | 1.3314 mL | 6.6569 mL | 13.3138 mL | 33.2845 mL | |
| 10 mM | 0.6657 mL | 3.3285 mL | 6.6569 mL | 16.6423 mL | |
| 15 mM | 0.4438 mL | 2.2190 mL | 4.4379 mL | 11.0948 mL | |
| 20 mM | 0.3328 mL | 1.6642 mL | 3.3285 mL | 8.3211 mL | |
| 25 mM | 0.2663 mL | 1.3314 mL | 2.6628 mL | 6.6569 mL | |
| 30 mM | 0.2219 mL | 1.1095 mL | 2.2190 mL | 5.5474 mL | |
| 40 mM | 0.1664 mL | 0.8321 mL | 1.6642 mL | 4.1606 mL | |
| 50 mM | 0.1331 mL | 0.6657 mL | 1.3314 mL | 3.3285 mL | |
| 60 mM | 0.1109 mL | 0.5547 mL | 1.1095 mL | 2.7737 mL | |
| 80 mM | 0.0832 mL | 0.4161 mL | 0.8321 mL | 2.0803 mL | |
| 100 mM | 0.0666 mL | 0.3328 mL | 0.6657 mL | 1.6642 mL |
4-Isopropylbenzyl alcohol Related Classifications
HY-N7069 Related Classifications
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