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Cat. No.: HY-N20671

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Apigenin 7-O-gentiobioside

Apigenin 7-O-gentiobioside is a flavonoid glycoside. Apigenin 7-O-gentiobioside antagonizes TNF-α-induced cytotoxicity. Apigenin 7-O-gentiobioside can be used in the research of inflammation-related diseases.

For research use only. We do not sell to patients.

CAS No.: 50826-94-3
Formula: C₂₇H₃₀O₁₅
Molecular Weight:594.52

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Apigenin 7-O-gentiobioside Chemical Structure

CAS No.: 50826-94-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Bioz

Biological Activity

Description

All TNF Receptor Isoforms :

In Vitro

Apigenin 7-O-gentiobioside (Compound 16) (3-100 μM; 44 h) significantly inhibits TNF-α-induced cytotoxicity in L929 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[2]

Cell Line:

L929 cells
Concentration:

3 μM, 10 μM, 30 μM, 100 μM+TNF-α (1ng/mL)
Incubation Time:

44 h
Result:

Inhibited TNF-α-induced cytotoxicity in L929 cells by 9.1%.
Inhibited TNF-α-induced cytotoxicity in L929 cells by 10.3%.
Inhibited TNF-α-induced cytotoxicity in L929 cells by 23.9% (statistically significant, p<0.01).
Inhibited TNF-α-induced cytotoxicity in L929 cells by 40.1% (statistically significant, p<0.01).

Chemical Information

CAS No. 50826-94-3
Molecular Weight 594.52
Formula C₂₇H₃₀O₁₅
SMILES

O=C1C2=C(O)C=C(O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)C=C2OC(C5=CC=C(C=C5)O)=C1
Structure Classification
- Flavonoids
- Flavones
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Masao Kikuchi, et al. Flavone Glycosides from Lonicera gracilipes var. glandulosa. J. Nat Prod. 1996, 59, 314-315.

[2]. Morikawa T, et al. Medicinal flowers. XXVII. New flavanone and chalcone glycosides, arenariumosides I, II, III, and IV, and tumor necrosis factor-alpha inhibitors from everlasting, flowers of Helichrysum arenarium. Chemical & pharmaceutical bulletin. 2009 Apr;57(4):361-7. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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Apigenin 7-O-gentiobioside

All TNF Receptor Isoforms