JNJ525
Based on 1 Customer Validation
JNJ525 is a TNFα inhibitor with IC50 values of 1.2 μM and 1.1 μM against TNFR1 and TNFR2, respectively. JNJ525 forms ordered aggregates and induces quaternary structural transition of TNFα, thereby blocking the protein-protein interaction between TNFα and its receptors. The inhibitory activity of JNJ525 is completely lost in the presence of 0.1% Triton X-100.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.93%
- CAS 番号: 2092913-64-7
- 分子式: C31H30N8
- 分子量:514.62
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
JNJ525 (Range; 1 h (with TNFα), 2 h (with receptor)) inhibits the protein-protein interaction between soluble human TNFα and its receptors TNFR1 and TNFR2 with apparent IC50 values of 1.2 μM and 1.1 μM, respectively, and this inhibitory activity is abrogated by 0.1% Triton X-100[1].
JNJ525 (Range; 30 min) forms aggregates with a critical aggregation concentration of 1 μM in both assay and crystallization buffers, and this aggregation is prevented by 0.1% Triton X-100[1].
JNJ525 (50 μM; 3 h) induces soluble human TNFα to shift from a trimer to a dimer associated with ~13 JNJ525 molecules, as measured by sedimentation velocity analytical ultracentrifugation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2092913-64-7
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性状 Solid
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分子量 514.62
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分子式 C31H30N8
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Color White to off-white
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SMILES
NC1=NC=CC(N(CC2=CC=CC=C2)C3=C(C4=CC(C5=CN=C(N6CCNCC6)N=C5)=CC=C4)C=CC=C3)=N1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 5 mg/mL (9.72 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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- Français - FR (251 KB)
- Deutsch - DE (251 KB)
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- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9432 mL | 9.7159 mL | 19.4318 mL | 48.5795 mL |
| 5 mM | 0.3886 mL | 1.9432 mL | 3.8864 mL | 9.7159 mL |
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