Neuroprotective agent 18
Neuroprotective agent 18 is a potent neuroprotective agent. Neuroprotective agent 18 inhibits the activity of NF-κB thereby significantly downregulating the expression of downstream pro-inflammatory mediators (TNF-α, IL-6) and inflammatory enzymes (COX-2) in the hippocampus. Neuroprotective agent 18 binds to AChE thereby partially inhibiting it and modulating cholinergic neurotransmission. Neuroprotective agent 18 can be used in research on Alzheimer's disease.
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- Fòrmula: C21H22N2O5
- Peso molecular:382.41
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
NF-κB |
COX-2 |
IL-6 |
TNF-α |
AChE |
In Vitro
Neuroprotective agent 18 (compound M5) is capable of binding favorably to multiple proteins involved in neuroinflammation. Neuroprotective agent 18 exhibits moderate to strong docking score (-7.9 kcal/mol, -7.7 kcal/mol, -7.3 kcal/mol and -7.1 kcal/mol) for COX-2, TNF-α, IL-6 complex and NF-κB. Neuroprotective agent 18 produces a comparatively stronger docking score (-9.0 kcal/mol) for AChE[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Swiss albino mice (Male, 8-10 weeks, 25-30 g) received daily intraperitoneal injections of Scopolamine (1 mg/kg) for 6 days[1].
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Dosage:1 mg/kg, 5 mg/kg, 10 mg/kg
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Administration:i.p.; once daily; for 6 days
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Result:Restored spatial learning and memory consolidation capabilities in a dose-dependent manner in the Morris Water Maze (MWM) test.
Effectively improved hippocampus-dependent short-term working memory in the Y-Maze Test.
Significantly reduced the concentrations of the pro-inflammatory cytokines TNF-α and IL-6 in the hippocampus in a dose-dependent manner, while simultaneously downregulating the expression levels of the inflammation-related enzyme COX-2 and the upstream inflammatory transcription factor NF-κB.
Chemical Information
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Peso molecular 382.41
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Fòrmula C21H22N2O5
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SMILES
O=C(ON=C/1CNCC2=CC=CC=C2)C1=C\C3=CC(OC)=C(OC)C(OC)=C3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Neuroprotective agent 18 Related Classifications
HY-184935 Related Classifications
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