Anti-inflammatory agent 107
Anti-inflammatory agent 107 is an orally active anti-inflammatory agent. Anti-inflammatory agent 107 inhibits and NF-κB with a superior binding affinity of -9.4578 kcal/mol. Anti-inflammatory agent 107 reduces levels of inflammatory biomarkers (TNF-α, IL-6, INF-γ, NF-κβ, C-reactive protein and Erythrocyte Sedimentation Rate) and enhances the endogenous antioxidant defense system by elevating SOD (Superoxide Dismutase), CAT (Catalase) and GSH (Glutathione) activities. Anti-inflammatory agent 107 not induces liver toxicity and demonstrates hepatoprotective effects. Anti-inflammatory agent 107 dose-dependently ameliorates leukocyte infiltration and tissue edema. Anti-inflammatory agent 107 can be used for anti-inflammatory research.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C29H20N6O9S
- Molecular Weight:628.57
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
NF-κB |
IL-6 |
mTOR |
In Vitro
Anti-inflammatory agent 107 (compound 4D) exerts a powerful anti-inflammatory by suppressing NF-κβ with a docking score of 9.4578 kcal/mol, the primary inflammatory protein signaling[1].
Anti-inflammatory agent 107 (50 μg/mL in 2 mL, 50 μg/mL in 0.02 mL) shows potent anti-inflammatory activity in both the human red blood cell membrane stabilization (anti-hemolytic) assay and the protein denaturation inhibition assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:κ-Carrageenan (0.1 mL of 1 % W/V, inject into the subplantar region of the right hind paw, once)-induced male (Sprague Dawley) rats (120-125 g, 6-8 weeks)[1].
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Dosage:20, 30 and 50 μg/kg
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Administration:p.o., once daily for a week
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Result:Showed gradually improvement at different doses.
Showed gradually improvement, gave very close results compare to aspirin at 30 μg/kg.
Reduced levels of inflammatory biomarkers (TNF-α, IL-6, INF-γ, NF-κβ, CRP and ESR) at he high-dose 50 μg/kg.
Showed excellent malondialdehyde (MDA) and nitric oxide (NO) improvement especially at 30 and 50 μg/kg.
Reduced GSH concentrations, returned CAT and SOD activities to nearly normal ranges.
Showed good regression in hepatic enzyme secretion, total bilirubin conjugation and excretion, and albumin biosynthesis.
Reversed the carrageenan-induced renal toxicity (characterized by increased urea and creatinine) and restored these parameters to near-normal ranges.
Produced dose-dependent improvements in histopathology, reducing leukocyte infiltration at lower doses and nearly eliminating edema while restoring normal skin architecture at the highest dose (50 μg/kg).
Chemical Information
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Molecular Weight 628.57
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Formel C29H20N6O9S
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SMILES
CCOC(C1=C(OC2=C(C1C3=CC=CO3)C(C4=CC=CS4)=NN2C5=CC=C(C=C5[N+]([O-])=O)[N+]([O-])=O)NC(C6=CN=CC=C6)=O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Anti-inflammatory agent 107 Related Classifications
HY-179502 Related Classifications
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