2. NF-κB Metabolic Enzyme/Protease Apoptosis Immunology/Inflammation PI3K/Akt/mTOR
  3. NF-κB Glutathione Peroxidase TNF Receptor Interleukin Related mTOR SOD
  4. Anti-inflammatory agent 107

Anti-inflammatory agent 107 is an orally active anti-inflammatory agent. Anti-inflammatory agent 107 inhibits and NF-κB with a superior binding affinity of -9.4578 kcal/mol. Anti-inflammatory agent 107 reduces levels of inflammatory biomarkers (TNF-α, IL-6, INF-γ, NF-κβ, C-reactive protein and Erythrocyte Sedimentation Rate) and enhances the endogenous antioxidant defense system by elevating SOD (Superoxide Dismutase), CAT (Catalase) and GSH (Glutathione) activities. Anti-inflammatory agent 107 not induces liver toxicity and demonstrates hepatoprotective effects. Anti-inflammatory agent 107 dose-dependently ameliorates leukocyte infiltration and tissue edema. Anti-inflammatory agent 107 can be used for anti-inflammatory research.

For research use only. We do not sell to patients.

Anti-inflammatory agent 107

Anti-inflammatory agent 107 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Anti-inflammatory agent 107 Related Antibodies

Top Publications Citing Use of Products

View All NF-κB Isoform Specific Products:

View All Isoforms
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

View All Glutathione Peroxidase Isoform Specific Products:

View All Isoforms
GPX1 GPX4

View All TNF Receptor Isoform Specific Products:

View All Isoforms
TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF10B/DR5/CD262 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

View All Interleukin Related Isoform Specific Products:

View All Isoforms
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

View All mTOR Isoform Specific Products:

View All Isoforms
mTOR mTORC1 mTORC2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Anti-inflammatory agent 107 is an orally active anti-inflammatory agent. Anti-inflammatory agent 107 inhibits and NF-κB with a superior binding affinity of -9.4578 kcal/mol. Anti-inflammatory agent 107 reduces levels of inflammatory biomarkers (TNF-α, IL-6, INF-γ, NF-κβ, C-reactive protein and Erythrocyte Sedimentation Rate) and enhances the endogenous antioxidant defense system by elevating SOD (Superoxide Dismutase), CAT (Catalase) and GSH (Glutathione) activities. Anti-inflammatory agent 107 not induces liver toxicity and demonstrates hepatoprotective effects. Anti-inflammatory agent 107 dose-dependently ameliorates leukocyte infiltration and tissue edema. Anti-inflammatory agent 107 can be used for anti-inflammatory research[1].

IC50 & Target[1]

NF-κB

 

IL-6

 

mTOR

 

In Vitro

Anti-inflammatory agent 107 (compound 4D) exerts a powerful anti-inflammatory by suppressing NF-κβ with a docking score of 9.4578 kcal/mol, the primary inflammatory protein signaling[1].
Anti-inflammatory agent 107 (50 μg/mL in 2 mL, 50 μg/mL in 0.02 mL) shows potent anti-inflammatory activity in both the human red blood cell membrane stabilization (anti-hemolytic) assay and the protein denaturation inhibition assay[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-inflammatory agent 107 Related Antibodies
In Vivo

Anti-inflammatory agent 107 (compound 4D) (20-50 μg/kg, p.o., once daily for a week) reduce inflammatory biomarkers, enhances and restores the antioxidant defenses (GSH, CAT, SOD) and renal toxicity, and reduces leukocyte infiltration in κ-Carrageenan (HY-138962)-induced paw edema rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: κ-Carrageenan (0.1 mL of 1 % W/V, inject into the subplantar region of the right hind paw, once)-induced male (Sprague Dawley) rats (120-125 g, 6-8 weeks)[1].
Dosage: 20, 30 and 50 μg/kg
Administration: p.o., once daily for a week
Result: Showed gradually improvement at different doses.
Showed gradually improvement, gave very close results compare to aspirin at 30 μg/kg.
Reduced levels of inflammatory biomarkers (TNF-α, IL-6, INF-γ, NF-κβ, CRP and ESR) at he high-dose 50 μg/kg.
Showed excellent malondialdehyde (MDA) and nitric oxide (NO) improvement especially at 30 and 50 μg/kg.
Reduced GSH concentrations, returned CAT and SOD activities to nearly normal ranges.
Showed good regression in hepatic enzyme secretion, total bilirubin conjugation and excretion, and albumin biosynthesis.
Reversed the carrageenan-induced renal toxicity (characterized by increased urea and creatinine) and restored these parameters to near-normal ranges.
Produced dose-dependent improvements in histopathology, reducing leukocyte infiltration at lower doses and nearly eliminating edema while restoring normal skin architecture at the highest dose (50 μg/kg).
Molecular Weight

628.57

Formula

C29H20N6O9S
SMILES

CCOC(C1=C(OC2=C(C1C3=CC=CO3)C(C4=CC=CS4)=NN2C5=CC=C(C=C5[N+]([O-])=O)[N+]([O-])=O)NC(C6=CN=CC=C6)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Anti-inflammatory agent 107 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 107NF-κBGlutathione PeroxidaseTNF ReceptorInterleukin RelatedmTORSODNuclear factor-κBNuclear factor-kappaBTumor Necrosis Factor ReceptorTNFRILMammalian target of RapamycinSuperoxide Dismutaseanti-inflammatory agentCATGSHInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Anti-inflammatory agent 107
Cat. No.:
HY-179502
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.