NF-κB-IN-15
NF-κB-IN-15 (compound 14r) is a potent NF-κB inhibitor. NF-κB-IN-15 decreases the NO levels and inhibits the release of IL-6, TNF-α, and IL-1β in LPS (HY-D1056) -induced cells. NF-κB-IN-15 inhibits LPS-induced phosphorylation of p65 and degradation of IκBα. NF-κB-IN-15 shows anti-inflammatory activity has the potential for the research of acute lung injury (ALI).
For research use only. We do not sell to patients.
- Formula: C46H58N4O8
- Molecular Weight:794.97
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
NF-κB-IN-15 (compound 14r) (1.25, 2.5, 5, 10, 20 µM; 1+24 h) decreases the NO levels in a dose-dependent manner and inhibits the release of IL-6, TNF-α, and IL-1β in LPS-induced RAW 264.7 cells[1].
NF-κB-IN-15 (10, 20 µM; 1+4 h) inhibits LPS-induced phosphorylation of p65 and degradation of IκBα[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW 264.7 cells[1]
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Concentration:10, 20 µM
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Incubation Time:1 h (LPS (1 μg/mL) for 4 h)
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Result:Decreased the expression of p-p65and inhibited degradation of IκBα. LPS-induced levels of IL-6, TNF-α, and IL-1β.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:18-20 g, Male C57BL/6 mice[1]
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Dosage:20 mg/kg+LPS (15 mg/kg, i. p.)
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Administration:I.p.
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Result:Reduced the LPS-induced levels of IL-6, TNF-α, and IL-1β in the bronchoalveolar lavage fluid (BALF) and acute lung injury.
Chemical Information
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Molecular Weight 794.97
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Formula C46H58N4O8
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SMILES
CC1=C(C)C=CC=C1N2CCN(C([C@H](CC3=CC(OC)=C(O)C(OC)=C3)[C@@H](C(N4CCN(C5=CC=CC(C)=C5C)CC4)=O)CC6=CC(OC)=C(O)C(OC)=C6)=O)CC2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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