TNF-α/IL-1β/IL-6-IN-1
TNF-α/IL-1β/IL-6-IN-1 is an anti-inflammatory agent. TNF-α/IL-1β/IL-6-IN-1 exerts anti-inflammatory effects by downregulating the expression of pro-inflammatory cytokines such as TNF-α, IL-1β and IL-6, and inhibiting the production of ROS. TNF-α/IL-1β/IL-6-IN-1 upregulates ABCG1 to promote cholesterol efflux. TNF-α/IL-1β/IL-6-IN-1 can be used in the research of inflammatory and lipid metabolic diseases such as atherosclerosis.
For research use only. We do not sell to patients.
- CAS No.: 3068223-93-5
- Formula: C20H17FN2O3S
- Molecular Weight:384.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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IL-6 |
IL-1β |
TNF-α/IL-1β/IL-6-IN-1 (compound 5j) at 1.25 μg/mL significantly reduces intracellular reactive oxygen species (ROS) levels in RAW 264.7 cells[1].
TNF-α/IL-1β/IL-6-IN-1 (1.25 μg/mL) reduces the mRNA and protein levels of TNF-α, IL-1β, and IL-6 in LPS (HY-D1056)-activated RAW 264.7 cells[1].
TNF-α/IL-1β/IL-6-IN-1 (1.25 μg/mL) significantly reduces lipid droplet area, intracellular cholesterol content, and upregulates ABCG1 levels in ox-LDL-induced RAW 264.7 foam cells[1].
TNF-α/IL-1β/IL-6-IN-1 (1.25-20 μg/mL; 24 h) shows no significant cytotoxicity in RAW 264.7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW 264.7
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Concentration:1.25 μg/mL, 2.5 μg/mL, 5 μg/mL, 10 μg/mL, and 20 μg/mL
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Incubation Time:24 h
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Result:Caused the cell viability of 100% in general and even approached 120%.
Chemical Information
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CAS No. 3068223-93-5
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Molecular Weight 384.42
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Formula C20H17FN2O3S
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SMILES
FC1=CC=C(C=C1)COC2=CC=C(C(NC3=CC=CC=C34)NS4(=O)=O)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TNF-α/IL-1β/IL-6-IN-1 Related Classifications
HY-181509 Related Classifications
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