2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Membrane Transporter/Ion Channel
  3. Reactive Oxygen Species (ROS) Interleukin Related ATP-binding cassette (ABC) transporters
  4. TNF-α/IL-1β/IL-6-IN-1

TNF-α/IL-1β/IL-6-IN-1 is an anti-inflammatory agent. TNF-α/IL-1β/IL-6-IN-1 exerts anti-inflammatory effects by downregulating the expression of pro-inflammatory cytokines such as TNF-α, IL-1β and IL-6, and inhibiting the production of ROS. TNF-α/IL-1β/IL-6-IN-1 upregulates ABCG1 to promote cholesterol efflux. TNF-α/IL-1β/IL-6-IN-1 can be used in the research of inflammatory and lipid metabolic diseases such as atherosclerosis.

For research use only. We do not sell to patients.

TNF-α/IL-1β/IL-6-IN-1

TNF-α/IL-1β/IL-6-IN-1 Chemical Structure

CAS No. : 3068223-93-5

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TNF-α/IL-1β/IL-6-IN-1 Related Antibodies

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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Description

TNF-α/IL-1β/IL-6-IN-1 is an anti-inflammatory agent. TNF-α/IL-1β/IL-6-IN-1 exerts anti-inflammatory effects by downregulating the expression of pro-inflammatory cytokines such as TNF-α, IL-1β and IL-6, and inhibiting the production of ROS. TNF-α/IL-1β/IL-6-IN-1 upregulates ABCG1 to promote cholesterol efflux. TNF-α/IL-1β/IL-6-IN-1 can be used in the research of inflammatory and lipid metabolic diseases such as atherosclerosis[1].

IC50 & Target[1]

IL-6

 

IL-1β

 

In Vitro

TNF-α/IL-1β/IL-6-IN-1 (compound 5j) at 1.25 μg/mL significantly reduces intracellular reactive oxygen species (ROS) levels in RAW 264.7 cells[1].
TNF-α/IL-1β/IL-6-IN-1 (1.25 μg/mL) reduces the mRNA and protein levels of TNF-α, IL-1β, and IL-6 in LPS (HY-D1056)-activated RAW 264.7 cells[1].
TNF-α/IL-1β/IL-6-IN-1 (1.25 μg/mL) significantly reduces lipid droplet area, intracellular cholesterol content, and upregulates ABCG1 levels in ox-LDL-induced RAW 264.7 foam cells[1].
TNF-α/IL-1β/IL-6-IN-1 (1.25-20 μg/mL; 24 h) shows no significant cytotoxicity in RAW 264.7 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TNF-α/IL-1β/IL-6-IN-1 Related Antibodies

Cell Viability Assay[1]

Cell Line: RAW 264.7
Concentration: 1.25 μg/mL, 2.5 μg/mL, 5 μg/mL, 10 μg/mL, and 20 μg/mL
Incubation Time: 24 h
Result: Caused the cell viability of 100% in general and even approached 120%.
Molecular Weight

384.42

Formula

C20H17FN2O3S
CAS No.
SMILES

FC1=CC=C(C=C1)COC2=CC=C(C(NC3=CC=CC=C34)NS4(=O)=O)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TNF-α/IL-1β/IL-6-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TNF-α/IL-1β/IL-6-IN-13068223-93-5Reactive Oxygen Species (ROS)Interleukin RelatedATP-binding cassette (ABC) transportersILATP-binding cassette transportersIL-6TNF-αcholesterol homeostasisreactive oxygen speciesatherosclerosismacrophage cellsfoam cell formationIL-1βABCG1Inhibitorinhibitorinhibit

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