rel-Cleroindicin F
rel-Cleroindicin F (Rengyolone) is a cyclohexyl acetyl compound that can be isolated from the fruit of forsythia and has anti-inflammatory activity. It strongly inhibits the production of nitric oxide (NO) and tumor necrosis factor-alpha (TNF-α). rel-Cleroindicin F does this by downregulating the activity of NF-κB and NF-κB kinases in RAW 264.7 cells stimulated by LPS (HY-D1056), thus inhibiting the expression of inducible nitric oxide synthase (NO Synthase) and nitric oxide production.
For research use only. We do not sell to patients.
- CAS No.: 94535-01-0
- Formula: C8H10O3
- Molecular Weight:154.16
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa S3 | IC50 |
2.8 μg/mL
Compound: 1
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Cytotoxicity against human HeLaS3 cells
Cytotoxicity against human HeLaS3 cells
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[PMID: 3236014] |
| P388 | IC50 |
2.1 μg/mL
Compound: 1
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Cytotoxicity against mouse P388 cells
Cytotoxicity against mouse P388 cells
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[PMID: 3236014] |
Chemical Information
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CAS No. 94535-01-0
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Molecular Weight 154.16
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Formula C8H10O3
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SMILES
O[C@@]12[C@@](OCC2)([H])CC(C=C1)=O
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Synonyms
Rengyolone
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
rel-Cleroindicin F Related Classifications
HY-N3602A Related Classifications
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