94535-01-0
Chemical Structure
rel-Cleroindicin F
Synonym(s): Rengyolone
- CAS No.: 94535-01-0
- Formula:C8H10O3
- Molecular Weight:154.16
IUPAC Name: (3aR,7aR)-3a-hydroxy-3,3a,7,7a-tetrahydrobenzofuran-6(2H)-one
InChIKey: HSGPAWIMHOPPDA-SFYZADRCSA-N
SMILES: O[C@@]12[C@@](OCC2)([H])CC(C=C1)=O
Biological Activity: rel-Cleroindicin F (Rengyolone) is a cyclohexyl acetyl compound that can be isolated from the fruit of forsythia and has anti-inflammatory activity. It strongly inhibits the production of nitric oxide (NO) and tumor necrosis factor-alpha (TNF-α). rel-Cleroindicin F does this by downregulating the activity of NF-κB and NF-κB kinases in RAW 264.7 cells stimulated by LPS (HY-D1056), thus inhibiting the expression of inducible nitric oxide synthase (NO Synthase) and nitric oxide production[1].
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rel-Cleroindicin F | rel-Cleroindicin F (Rengyolone) is a cyclohexyl acetyl compound that can be isolated from the fruit of forsythia and has anti-inflammatory activity. It strongly inhibits the production of nitric oxide (NO) and tumor necrosis factor-alpha (TNF-α). rel-Cleroindicin F does this by downregulating the activity of NF-κB and NF-κB kinases in RAW 264.7 cells stimulated by LPS (HY-D1056), thus inhibiting the expression of inducible nitric oxide synthase (NO Synthase) and nitric oxide production. | |||||||||||||||||||||
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Keywords
