a15:0-i15:0 PE
a15:0-i15:0 PE is an atypical TLR2 agonist, and its immune signaling strictly depends on the TLR2-TLR1 heterodimer. a15:0-i15:0 PE induces dendritic cells to produce TNFα and IL-6, but does not induce the production of IL-10 or IL-12p70. At low doses, a15:0-i15:0 PE resets the activation threshold of immune cells to suppress or regulate immune responses against specific agonists.
For research use only. We do not sell to patients.
- CAS No.: 2936622-21-6
- Formula: C35H70NO8P
- Molecular Weight:663.91
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
TLR2 |
IL-6 |
In Vitro
a15:0-i15:0 PE (50 μg/mL; overnight) induces TNFα and IL-6 release from murine bone-marrow-derived dendritic cells via a TLR2-dependent pathway, with no induction of IL-10 or IL-12p70[1].
a15:0-i15:0 PE (50 μg/mL; overnight) requires distinct branched-chain acyl groups for TNFα-inducing activity in murine bone-marrow-derived dendritic cells, with positional isomer i15:0-a15:0 showing partial activity[1].
a15:0-i15:0 PE (0.1-10 μg/mL; 3-21 h) induces TNFα release from human monocyte-derived dendritic cells via a TLR2-TLR1 heterodimer-dependent pathway, and low-dose pre-treatment for 18 h suppresses subsequent TNFα responses to Pam3CSK4 and moderates responses to LPS[1].
a15:0-i15:0 PE (50 μg/mL; 6 h) induces pro-inflammatory cytokine gene expression (TNFα, IL-6) in human peripheral blood monocytes, with limited induction of IL-23A and IL-12B[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2936622-21-6
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Appearance Solid
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Molecular Weight 663.91
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Formula C35H70NO8P
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Color White to off-white
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SMILES
NCCOP(OC[C@H](OC(CCCCCCCCCCCC(C)C)=O)COC(CCCCCCCCCC[C@H](CC)C)=O)(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
a15:0-i15:0 PE Related Classifications
HY-N15936 Related Classifications
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Keywords