1. Metabolic Enzyme/Protease
    Apoptosis
  2. Phosphodiesterase (PDE)
    TNF Receptor
    Apoptosis
  3. Apremilast D5

Apremilast D5 (Synonyms: CC-10004 D5)

Cat. No.: HY-12085S
Handling Instructions

Apremilast D5 (CC-10004 D5) is a deuterium labeled Apremilast. Apremilast is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC50 of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC50 of 104 nM.

For research use only. We do not sell to patients.

Apremilast D5 Chemical Structure

Apremilast D5 Chemical Structure

CAS No. : 1258597-47-5

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Description

Apremilast D5 (CC-10004 D5) is a deuterium labeled Apremilast. Apremilast is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC50 of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC50 of 104 nM[1].

IC50 & Target[1]

PDE4

 

TNF-α

 

Molecular Weight

465.53

Formula

C₂₂H₁₉D₅N₂O₇S

CAS No.

1258597-47-5

SMILES

CC(NC1=CC=CC(C(N2[[email protected]@H](C3=CC=C(OC)C(OC([2H])([2H])C([2H])([2H])[2H])=C3)CS(=O)(C)=O)=O)=C1C2=O)=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Apremilast D5CC-10004 D5Apremilast D 5Apremilast D-5Phosphodiesterase (PDE)TNF ReceptorApoptosisTumor Necrosis Factor ReceptorTNFRorallyavailabletype-4cyclicnucleotidephosphodiesterasePDE-4,TNF-αlipopolysaccharideLPSPBMCInhibitorinhibitorinhibit

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