2. Metabolic Enzyme/Protease
    Apoptosis
  3. Phosphodiesterase (PDE)
    TNF Receptor
    Apoptosis
  4. Apremilast-d5

Apremilast-d5  (Synonyms: CC-10004-d5)

Cat. No.: HY-12085S Purity: 98.63%
COA Handling Instructions

Apremilast-d5 is a deuterium labeled Apremilast. Apremilast is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC50 of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC50 of 104 nM[1].

For research use only. We do not sell to patients.

Apremilast-d<sub>5</sub> Chemical Structure

Apremilast-d5 Chemical Structure

CAS No. : 1258597-47-5

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1 mg USD 330 In-stock
Estimated Time of Arrival: December 31
5 mg USD 900 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1440 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Apremilast-d5 is a deuterium labeled Apremilast. Apremilast is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC50 of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC50 of 104 nM[1].

IC50 & Target[1]

PDE4

 

Molecular Weight

465.53

Appearance

Solid

Formula

C22H19D5N2O7S
CAS No.
SMILES

CC(NC1=CC=CC(C(N2[[email protected]@H](C3=CC=C(OC)C(OC([2H])([2H])C([2H])([2H])[2H])=C3)CS(=O)(C)=O)=O)=C1C2=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Apremilast-d51258597-47-5CC-10004-d5Phosphodiesterase (PDE)TNF ReceptorApoptosisTumor Necrosis Factor ReceptorTNFRorallyavailabletype-4cyclicnucleotidephosphodiesterasePDE-4,TNF-αlipopolysaccharideLPSPBMCInhibitorinhibitorinhibit

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