1. GPCR/G Protein
  2. Cannabinoid Receptor

A-836339 

Cat. No.: HY-12761 Purity: 99.61%
Handling Instructions

A-836339 is a cannabinoid CB2 receptor-selective agonist; exhibits high potencies at CB(2) and selectivity over CB(1) receptors.

For research use only. We do not sell to patients.
A-836339 Chemical Structure

A-836339 Chemical Structure

CAS No. : 959746-77-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 164 In-stock
1 mg USD 60 In-stock
5 mg USD 240 In-stock
10 mg USD 420 In-stock
50 mg USD 1260 In-stock
100 mg   Get quote  
200 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

A-836339 is a cannabinoid CB2 receptor-selective agonist; exhibits high potencies at CB(2) and selectivity over CB(1) receptors. IC50 value: 1.6 nM(EC50) [1] Target: CB2 agonist in vitro: In radioligand binding assays, A-836339 displays high affinities at CB(2) receptors and selectivity over CB(1) receptors in both human and rat.In addition A-836339 exhibits a profile devoid of significant affinity at other G-protein-coupled receptors and ion channels [1]. in vivo: In the complete Freund's adjuvant model of inflammatory pain, A-836339 exhibits a potent CB(2) receptor-mediated antihyperalgesic effect that is independent of CB(1) or mu-opioid receptors. A-836339 has also demonstrated efficacies in the chronic constrain injury (CCI) model of neuropathic pain, skin incision, and capsaicin-induced secondary mechanical hyperalgesia models [1]. Similar to systemic delivery, intra-spinal injection of A-836339 (0.3 and 1 nmol) also attenuated both von Frey-evoked and spontaneous firing of WDR neurons in neuropathic rats. Intra-spinal injections of A-836339 were ineffective in sham rats [2]. Systemic A-836339 and AM1241 produced dose-dependent efficacy in both inflammatory and neuropathic pain models. Local administration of CB? agonists also produced significant analgesic effects in SNL (intra-DRG and i.t.) and CFA (intra-DRG) pain models [3].

References
Molecular Weight

310.45

Formula

C₁₆H₂₆N₂O₂S

CAS No.

959746-77-1

SMILES

CC1=C(C)S/C(N1CCOC)=N\C(C2C(C)(C)C2(C)C)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: 12 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
A-836339
Cat. No.:
HY-12761
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