PKC-IN-4
PKC-IN-4 (compound 7l) is a potent and orally active aPKC inhibitor with an IC50 of 0.52 µM. PKC-IN-4 inhibits TNF-α induced NF-κB activity in vitro. PKC-IN-4 blocks VEGF- and TNFα-induced permeability across the retinal vasculature.
For research use only. We do not sell to patients.
- CAS No.: 2636771-29-2
- Formula: C21H25N5S
- Molecular Weight:379.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PKC 0.52 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
6.65 μM
Compound: 7l
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Inhibition of TNFalpha-induced NFkappaB activation in HEK293 cells preincubated for 2 hrs followed by TNFalpha stimulation by luciferase assay
Inhibition of TNFalpha-induced NFkappaB activation in HEK293 cells preincubated for 2 hrs followed by TNFalpha stimulation by luciferase assay
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[PMID: 32327351] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Animal Model: CD-1 mice[1]
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Dosage:10, 20 mg/kg
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Administration:10 mg/kg for i.v.; 20 mg/kg for p.o.
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Result:Showed good PK parameters with oral bioavailability of 81.7%.
Chemical Information
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CAS No. 2636771-29-2
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Molecular Weight 379.52
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Formula C21H25N5S
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SMILES
NCC1CCN(CC1)C2=NC(C3=CC=NC=C3)=NC4=C2C5=C(S4)CCCC5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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