SHP2-IN-45
SHP2-IN-45 (Compound 6) is a potent, highly selective, and orally active SHP2 allosteric inhibitor. SHP2-IN-45 significantly reduces the expressions of IL-6, TNF-α, IL-1β, and iNOS. SHP2-IN-45 inhibits the polarization of M1-type macrophages. SHP2-IN-45 can inhibit the NF-κB pathway. SHP2-IN-45 can be used in the research of sepsis and acute lung injury.
For research use only. We do not sell to patients.
- CAS No.: 2949435-53-2
- Formula: C20H21ClN6S
- Molecular Weight:412.94
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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IL-6 |
IL-1β |
iNOS |
NF-κB |
Chemical Information
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CAS No. 2949435-53-2
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Molecular Weight 412.94
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Formula C20H21ClN6S
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SMILES
CC1=C2C([C@H](CCN(C3=NC=C(SC4=CC=NC(N)=C4Cl)N=C3)C2)N)=CC=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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