2949435-53-2
2949435-53-2
Chemical Structure
SHP2-IN-45
- CAS No.: 2949435-53-2
- Formula:C20H21ClN6S
- Molecular Weight:412.94
InChIKey: KYJJAEJOVDNACG-HNNXBMFYSA-N
SMILES: CC1=C2C([C@H](CCN(C3=NC=C(SC4=CC=NC(N)=C4Cl)N=C3)C2)N)=CC=C1
Biological Activity: SHP2-IN-45 (Compound 6) is a potent, highly selective, and orally active SHP2 allosteric inhibitor. SHP2-IN-45 significantly reduces the expressions of IL-6, TNF-α, IL-1β, and iNOS. SHP2-IN-45 inhibits the polarization of M1-type macrophages. SHP2-IN-45 can inhibit the NF-κB pathway. SHP2-IN-45 can be used in the research of sepsis and acute lung injury[1].
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SHP2-IN-45 | SHP2-IN-45 (Compound 6) is a potent, highly selective, and orally active SHP2 allosteric inhibitor. SHP2-IN-45 significantly reduces the expressions of IL-6, TNF-α, IL-1β, and iNOS. SHP2-IN-45 inhibits the polarization of M1-type macrophages. SHP2-IN-45 can inhibit the NF-κB pathway. SHP2-IN-45 can be used in the research of sepsis and acute lung injury. | |||||||||||||||||||||
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