2. MAPK/ERK Pathway
  3. p38 MAPK
  4. p38 MAP Kinase Inhibitor III

p38 MAP Kinase Inhibitor III 

Cat. No.: HY-112389 Purity: ≥98.0%
COA Handling Instructions

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p38 MAP Kinase Inhibitor III (compound 7h) is a p38 MAPK inhibitor with an 50 of 0.9 μM. p38 MAP Kinase Inhibitor III also inhibits IL-1β and TNF-α release with 50 values of 0.37 μM and 0.044 μM, respectively.

For research use only. We do not sell to patients.

p38 MAP Kinase Inhibitor III Chemical Structure

p38 MAP Kinase Inhibitor III Chemical Structure

CAS No. : 581098-48-8

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Based on 1 publication(s) in Google Scholar

p38 MAP Kinase Inhibitor III Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE p38 MAP Kinase Inhibitor III

View All p38 MAPK Isoform Specific Products:

View All Isoforms
p38 MAPK p38α p38β MAPK13 p38δ p38γ

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Description

p38 MAP Kinase Inhibitor III (compound 7h) is a p38 MAPK inhibitor with an 50 of 0.9 μM. p38 MAP Kinase Inhibitor III also inhibits IL-1β and TNF-α release with 50 values of 0.37 μM and 0.044 μM, respectively[1].

IC50 & Target[1]

p38 MAP kinase

0.9 μM (IC50)

Molecular Weight

404.50

Formula

C23H21FN4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@H](NC1=NC=CC(C2=C(C3=CC=C(F)C=C3)NC(SC)=N2)=C1)C4=CC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMF : 20 mg/mL (49.44 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4722 mL 12.3609 mL 24.7219 mL
5 mM 0.4944 mL 2.4722 mL 4.9444 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (252 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMF 1 mM 2.4722 mL 12.3609 mL 24.7219 mL 61.8047 mL
5 mM 0.4944 mL 2.4722 mL 4.9444 mL 12.3609 mL
10 mM 0.2472 mL 1.2361 mL 2.4722 mL 6.1805 mL
15 mM 0.1648 mL 0.8241 mL 1.6481 mL 4.1203 mL
20 mM 0.1236 mL 0.6180 mL 1.2361 mL 3.0902 mL
25 mM 0.0989 mL 0.4944 mL 0.9889 mL 2.4722 mL
30 mM 0.0824 mL 0.4120 mL 0.8241 mL 2.0602 mL
40 mM 0.0618 mL 0.3090 mL 0.6180 mL 1.5451 mL
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p38 MAP Kinase Inhibitor III Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

p38 MAP Kinase Inhibitor III581098-48-8p38 MAPKIL-1βTNF-αInhibitorinhibitorinhibit

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