PI3K/AKT-IN-6
PI3K/AKT-IN-6 is an orally effective PI3K/AKT signaling pathway inhibitor and anti-inflammatory agent. PI3K/AKT-IN-6 inhibits the production of pro-inflammatory cytokines TNF-α and IL-6, and downregulates the expression of inflammatory mediators COX-2 and iNOS. PI3K/AKT-IN-6 improves related symptoms in colitis mice. PI3K/AKT-IN-6 can be used for the research of inflammatory diseases such as colitis.
For research use only. We do not sell to patients.
- Formula: C23H25Cl2FN2O5
- Molecular Weight:499.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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COX-2 |
IL-6 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J treated DSS (22-25 g)[1]
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Dosage:20 mg/kg
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Administration:p.o.; daily; 7 days
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Result:Reduced mean body weight loss, with body weigh.
Reduced disease activity index (DAI).
Reduced serum TNF-α, IL-6 levels.
Reduced iNOS/GAPDH, COX-2/GAPDH, p-PI3K/PI3K, p-AKT/AKT ratio in colonic tissue.
Reduced inflammatory cell infiltration and improved goblet cell damage in colon tissue.
Chemical Information
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Molecular Weight 499.36
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Formula C23H25Cl2FN2O5
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SMILES
O[C@@H]1C=C(C(NC23C[C@@H](C4)C[C@H](C3)CC4C2)=O)C[C@@H](OC(C5=C(Cl)N=C(Cl)C(F)=C5)=O)[C@@H]1O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PI3K/AKT-IN-6 Related Classifications
HY-182282 Related Classifications
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