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Cat. No.: HY-182282

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PI3K/AKT-IN-6

PI3K/AKT-IN-6 is an orally effective PI3K/AKT signaling pathway inhibitor and anti-inflammatory agent. PI3K/AKT-IN-6 inhibits the production of pro-inflammatory cytokines TNF-α and IL-6, and downregulates the expression of inflammatory mediators COX-2 and iNOS. PI3K/AKT-IN-6 improves related symptoms in colitis mice. PI3K/AKT-IN-6 can be used for the research of inflammatory diseases such as colitis.

For research use only. We do not sell to patients.

Formula: C₂₃H₂₅Cl₂FN₂O₅
Molecular Weight:499.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PI3K/AKT-IN-6 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

COX-2

IL-6

All PI3K Isoforms :

All Akt Isoforms :

All NO Synthase Isoforms :

All COX Isoforms :

All Interleukin Related Isoforms :

In Vitro

PI3K/AKT-IN-6 (compound 110) (10 μM) inhibits LPS (HY-D1056)-induced NO production in RAW 264.7 macrophages without significant cytotoxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PI3K/AKT-IN-6 (20 mg/kg; p.o.; daily; 7 days) significantly ameliorates DSS-induced ulcerative colitis in mice, reducing disease activity index, pro-inflammatory cytokine levels, inflammatory mediator expression, and PI3K/AKT pathway activation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J treated DSS (22-25 g)^[1]
Dosage:

20 mg/kg
Administration:

p.o.; daily; 7 days
Result:

Reduced mean body weight loss, with body weigh.
Reduced disease activity index (DAI).
Reduced serum TNF-α, IL-6 levels.
Reduced iNOS/GAPDH, COX-2/GAPDH, p-PI3K/PI3K, p-AKT/AKT ratio in colonic tissue.
Reduced inflammatory cell infiltration and improved goblet cell damage in colon tissue.

Chemical Information

Molecular Weight 499.36
Formula C₂₃H₂₅Cl₂FN₂O₅
SMILES

O[C@@H]1C=C(C(NC23C[C@@H](C4)C[C@H](C3)CC4C2)=O)C[C@@H](OC(C5=C(Cl)N=C(Cl)C(F)=C5)=O)[C@@H]1O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Xie H, et al. Design, synthesis and evaluation of shikimic acid derivatives for the treatment of ulcerative colitis. Eur J Med Chem. 2026;309:118762. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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PI3K/AKT-IN-6

All PI3K Isoforms

All Akt Isoforms

All NO Synthase Isoforms

All COX Isoforms

All Interleukin Related Isoforms