Siaresinolic acid
Siaresinolic acid is a compound found in the leaves of Sabicea grisea. Siaresinolic acid shows antinociceptive and anti-inflammatory activity. Siaresinolic acid reduces nociceptive behavior by ATP-dependent potassium channel, inhibits leukocyte influx, plasma leakage, and proinflammatory mediator (TNF-α, IL-1β) production. Siaresinolic acid does not induce cytotoxicity in murine macrophages, alter locomotor activity at high doses. Siaresinolic acid can be used for the research of pleurisy and pain.
For research use only. We do not sell to patients.
- CAS No.: 511-77-3
- Formula: C30H48O4
- Molecular Weight:472.70
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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IL-1β |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
42.57 μM
Compound: SA
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Cytotoxicity against human A549 cells assessed as cell viability after 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as cell viability after 72 hrs by MTT assay
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[PMID: 23992864] |
Siaresinolic acid (1-200 μg/mL; 24 h) is non-cytotoxic to murine peritoneal macrophages[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Siaresinolic acid (1 mg/kg; i.p.; 1 hour before formalin injection) selectively inhibits the inflammatory phase of formalin-induced nociception in mice[1].
Siaresinolic acid (0.01-1 mg/kg; i.p.; 1 hour before carrageenan injection) dose-dependently inhibits acute inflammatory responses in Carrageenan (HY-125474)-induced pleurisy, with 1 mg/kg producing >82% inhibition of key proinflammatory mediators[1].
Siaresinolic acid (1 mg/kg; i.p.) does not produce central antinociception in the hot plate test in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Acetic acid-induced Swiss mice (male, 18-22 g)[1]
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Dosage:0.01 mg/kg; 0.1 mg/kg; 1 mg/kg; 10 mg/kg
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Administration:I.p.; 1 hour before acetic acid injection
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Result:Produced no alteration in nociceptive behavior at 0.01 mg/kg.
Reduced the number of abdominal writhes by 42.3% at 0.1 mg/kg.
Reduced the number of abdominal writhes by 58.2% at 1 mg/kg.
Reduced the number of abdominal writhes by 70.9% at 10 mg/kg.
Had its antinociceptive effect fully blocked by pretreatment with Glibenclamide (HY-15206) at 1 mg/kg.
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Animal Model:Carrageenan-induced Swiss mice (male, 18-22 g)[1]
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Dosage:0.01 mg/kg; 0.1 mg/kg; 1 mg/kg
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Administration:I.p.; 1 hour before carrageenan injection
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Result:Significantly reduced total leukocyte count, neutrophil count, and plasma leakage at all tested doses.
Left mononuclear cell count unaffected at all tested doses.
Reduced TNF-α levels by 82.3% at 1 mg/kg.
Reduced IL-1β levels by 95.7% at 1 mg/kg.
Reduced CXCL1 levels by 89.3% at 1 mg/kg.
Chemical Information
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CAS No. 511-77-3
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Molecular Weight 472.70
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Formula C30H48O4
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SMILES
OC([C@]12[C@]([C@@H](C(C)(CC2)C)O)([H])C3=CC[C@@]([C@@]4([C@@](C(C)([C@H](CC4)O)C)([H])CC5)C)([H])[C@]5(C)[C@@]3(CC1)C)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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