2. Membrane Transporter/Ion Channel Apoptosis Immunology/Inflammation
  3. Potassium Channel TNF Receptor Interleukin Related
  4. Siaresinolic acid

Siaresinolic acid is a compound found in the leaves of Sabicea grisea. Siaresinolic acid shows antinociceptive and anti-inflammatory activity. Siaresinolic acid reduces nociceptive behavior by ATP-dependent potassium channel, inhibits leukocyte influx, plasma leakage, and proinflammatory mediator (TNF-α, IL-1β) production. Siaresinolic acid does not induce cytotoxicity in murine macrophages, alter locomotor activity at high doses. Siaresinolic acid can be used for the research of pleurisy and pain.

For research use only. We do not sell to patients.

Siaresinolic acid

Siaresinolic acid Chemical Structure

CAS No. : 511-77-3

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Siaresinolic acid Related Antibodies

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Description

Siaresinolic acid is a compound found in the leaves of Sabicea grisea. Siaresinolic acid shows antinociceptive and anti-inflammatory activity. Siaresinolic acid reduces nociceptive behavior by ATP-dependent potassium channel, inhibits leukocyte influx, plasma leakage, and proinflammatory mediator (TNF-α, IL-1β) production. Siaresinolic acid does not induce cytotoxicity in murine macrophages, alter locomotor activity at high doses. Siaresinolic acid can be used for the research of pleurisy and pain[1].

IC50 & Target[1]

IL-1β

 

In Vitro

Siaresinolic acid (1-200 μg/mL; 24 h) is non-cytotoxic to murine peritoneal macrophages[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Siaresinolic acid Related Antibodies
In Vivo

Siaresinolic acid (0.1-10 mg/kg; i.p.; 1 hour before acetic acid injection) produces dose-dependent peripheral antinociception in the Acetic acid (HY-Y0319)-induced writhing model, with a maximum 70.9% inhibition at 10 mg/kg[1].
Siaresinolic acid (1 mg/kg; i.p.; 1 hour before formalin injection) selectively inhibits the inflammatory phase of formalin-induced nociception in mice[1].
Siaresinolic acid (0.01-1 mg/kg; i.p.; 1 hour before carrageenan injection) dose-dependently inhibits acute inflammatory responses in Carrageenan (HY-125474)-induced pleurisy, with 1 mg/kg producing >82% inhibition of key proinflammatory mediators[1].
Siaresinolic acid (1 mg/kg; i.p.) does not produce central antinociception in the hot plate test in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Acetic acid-induced Swiss mice (male, 18-22 g)[1]
Dosage: 0.01 mg/kg; 0.1 mg/kg; 1 mg/kg; 10 mg/kg
Administration: I.p.; 1 hour before acetic acid injection
Result: Produced no alteration in nociceptive behavior at 0.01 mg/kg.
Reduced the number of abdominal writhes by 42.3% at 0.1 mg/kg.
Reduced the number of abdominal writhes by 58.2% at 1 mg/kg.
Reduced the number of abdominal writhes by 70.9% at 10 mg/kg.
Had its antinociceptive effect fully blocked by pretreatment with Glibenclamide (HY-15206) at 1 mg/kg.
Animal Model: Carrageenan-induced Swiss mice (male, 18-22 g)[1]
Dosage: 0.01 mg/kg; 0.1 mg/kg; 1 mg/kg
Administration: I.p.; 1 hour before carrageenan injection
Result: Significantly reduced total leukocyte count, neutrophil count, and plasma leakage at all tested doses.
Left mononuclear cell count unaffected at all tested doses.
Reduced TNF-α levels by 82.3% at 1 mg/kg.
Reduced IL-1β levels by 95.7% at 1 mg/kg.
Reduced CXCL1 levels by 89.3% at 1 mg/kg.
Molecular Weight

472.70

Formula

C30H48O4
CAS No.
SMILES

OC([C@]12[C@]([C@@H](C(C)(CC2)C)O)([H])C3=CC[C@@]([C@@]4([C@@](C(C)([C@H](CC4)O)C)([H])CC5)C)([H])[C@]5(C)[C@@]3(CC1)C)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Siaresinolic acid Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Siaresinolic acid511-77-3Potassium ChannelTNF ReceptorInterleukin RelatedKcsATumor Necrosis Factor ReceptorTNFRILacetic acidmurine macrophagesleukocyteantinociceptiveformalinnociceptioncarrageenanpleurisyanti-inflammatoryInhibitorinhibitorinhibit

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