2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. Atizoram

Atizoram (CP-80,633) is an orally active phosphodiesterase type 4 (PDE4) inhibitor. Atizoram blocks cAMP degradation, thereby increasing intracellular and plasma cAMP levels. Atizoram inhibits TNFα release. Atizoram can be used in research related to acute respiratory distress syndrome.

For research use only. We do not sell to patients.

Atizoram

Atizoram Chemical Structure

CAS No. : 135637-46-6

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500 μg In-stock

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Based on 1 publication(s) in Google Scholar

Atizoram Related Antibodies

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Description

Atizoram (CP-80,633) is an orally active phosphodiesterase type 4 (PDE4) inhibitor. Atizoram blocks cAMP degradation, thereby increasing intracellular and plasma cAMP levels. Atizoram inhibits TNFα release. Atizoram can be used in research related to acute respiratory distress syndrome[1][2].

IC50 & Target[1]

PDE4

 

In Vitro

Atizoram increases intracellular cAMP levels and inhibits TNFα release from monocytes in vitro[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Atizoram Related Antibodies
In Vivo

Atizoram (1-32 mg/kg; p.o.; single dose) administered orally to male Balb/c mice dose-dependently elevates plasma cAMP (with a 6-fold increase at 10 mg/kg p.o.) and epinephrine, with the cAMP effect lasting up to 250 minutes, and propranolol significantly reduces the cAMP response in control mice[1].
Atizoram (1-30 mg/kg; p.o.; single dose) administered orally dose-dependently inhibits LPS-induced serum TNFα production in mice, with a slight reduction in potency after adrenalectomy (ED50 1.2 mg/kg p.o. in controls vs. 3.9 mg/kg p.o. in adx mice)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c (male, 20-25 g)[1]
Dosage: 1 mg/kg; 3.2 mg/kg; 10 mg/kg; 32 mg/kg
Administration: p.o.; single dose
Result: Elevated plasma cAMP in a dose-dependent manner.
Elevated plasma cAMP levels as early as 10 minutes after 3.2 mg/kg p.o. dosing and remained elevated for up to 250 minutes.
Caused a 6-fold increase in plasma cAMP (from 61.1 to 360.4 pmol/mL, n=9, P<.05) at 10 mg/kg p.o. in control mice; did not significantly alter plasma cGMP levels (vehicle: 48.7 pmol/mL vs.
Atizoram: 35.7 pmol/mL, n=4, P>.05).
Caused a 2-fold increase in plasma epinephrine levels at 10 mg/kg p.o.
Animal Model: Balb/c (male, 20-25 g, adrenalectomized or sham-operated)[1]
Dosage: 1 mg/kg; 3 mg/kg; 10 mg/kg; 30 mg/kg
Administration: p.o.; single dose
Result: Dose-dependently reduced LPS-induced serum TNFα production, with an ED50 of 1.2 mg/kg p.o. in control mice and an ED50 of 3.9 mg/kg p.o. in adrenalectomized mice.
Caused a greater than 95% reduction in TNFα production in control mice at 10 mg/kg p.o.
Molecular Weight

316.39

Formula

C18H24N2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COC(C=CC(C1CNC(NC1)=O)=C2)=C2O[C@@H]3[C@@H]4C[C@@H](CC4)C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMF : 3 mg/mL (9.48 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1607 mL 15.8033 mL 31.6066 mL
5 mM 0.6321 mL 3.1607 mL 6.3213 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 96.3%

SDS (252 KB)

COA (248 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMF 1 mM 3.1607 mL 15.8033 mL 31.6066 mL 79.0164 mL
5 mM 0.6321 mL 3.1607 mL 6.3213 mL 15.8033 mL
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Atizoram Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Atizoram135637-46-6CP-80,633Phosphodiesterase (PDE)human monocytesPDE4cAMPBalb/c miceacute respiratory distress syndromeTNFαphosphodiesterase Type 4adrenal glandisolated perfused rat lungspulmonary hemodynamicsInhibitorinhibitorinhibit

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