135637-46-6
Chemical Structure
Atizoram
Synonym(s): CP-80,633
- CAS No.: 135637-46-6
- Formula:C18H24N2O3
- Molecular Weight:316.39
IUPAC Name: 5-(3-(((1S,2S,4R)-bicyclo[2.2.1]heptan-2-yl)oxy)-4-methoxyphenyl)tetrahydropyrimidin-2(1H)-one
InChIKey: LITNEAPWQHVPOK-FFSVYQOJSA-N
SMILES: COC(C=CC(C1CNC(NC1)=O)=C2)=C2O[C@@H]3[C@@H]4C[C@@H](CC4)C3
Biological Activity: Atizoram (CP-80,633) is an orally active phosphodiesterase type 4 (PDE4) inhibitor. Atizoram blocks cAMP degradation, thereby increasing intracellular and plasma cAMP levels. Atizoram inhibits TNFα release. Atizoram can be used in research related to acute respiratory distress syndrome[1][2].
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Atizoram | Atizoram (CP-80,633) is an orally active phosphodiesterase type 4 (PDE4) inhibitor. Atizoram blocks cAMP degradation, thereby increasing intracellular and plasma cAMP levels. Atizoram inhibits TNFα release. Atizoram can be used in research related to acute respiratory distress syndrome. | |||||||||||||||||||||
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- [1]. Cheng JB, et al. The phosphodiesterase type 4 (PDE4) inhibitor CP-80,633 elevates plasma cyclic AMP levels and decreases tumor necrosis factor-alpha (TNFalpha) production in mice: effect of adrenalectomy. J Pharmacol Exp Ther. 1997;280(2):621-626. [Content Brief]
- [2]. Waypa GB, et al. Oxidant-increased endothelial permeability: prevention with phosphodiesterase inhibition vs. cAMP production. J Appl Physiol (1985). 2000;88(3):835-842. [Content Brief]
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