ASK1-IN-12
ASK1-IN-12 is an ASK1 inhibitor with an IC50 of 6.3 nM. ASK1-IN-12 inhibits TNF-α-induced activation of the ASK1-p38/JNK pathway. ASK1-IN-12 can reduce free fatty acid-induced cholesterol increase, lipid droplet accumulation and improves hepatocellular steatosis. ASK1-IN-12 can be used for the research of non-alcoholic steatohepatitis (NASH).
For research use only. We do not sell to patients.
- Formula: C24H22F3N9O
- Molecular Weight:509.49
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
ASK1-IN-12 (Compound 20) (1-6 μM; 24 h) reduces total cholesterol, triglyceride, low-density lipoprotein cholesterol and lipid droplet accumulation and improves hepatocellular steatosis in free fatty acid-induced LO2 cells[1].
ASK1-IN-12 (1-1000 nM; 24 h) inhibits TNF-α-induced activation of the ASK1-p38/JNK pathway in HepG2 cells[1].
ASK1-IN-12 (0.5-5 μM; 24 h) exhibits no significant cytotoxicity to LO2 hepatocytes, with cell viability maintained above 80%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HepG2 cells
-
Concentration:1, 10, 100 and 1000 nM
-
Incubation Time:24 h
-
Result:Reducd the phosphorylation ratios of p-ASK1/ASK1, p-JNK/JNK, and p-p38/p38.
Chemical Information
-
Molecular Weight 509.49
-
Formula C24H22F3N9O
-
SMILES
O=C(NC1=CC=CC(C2=NN=CN2[C@H](C(F)(F)F)C)=N1)C3=NN4C=CC(C5=CN(C(C)C)N=C5)=CC4=C3
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ASK1-IN-12 Related Classifications
HY-179517 Related Classifications
Powered by Bioz