Onfekafusp alfa
Onfekafusp alfa (L19TNF) is a homotrimer that forms from engineered peptides for the L19 antibody in scFv format fused to human TNF. Onfekafusp alfa can be used for malignant glioma research.
For research use only. We do not sell to patients.
- CAS No.: 1957239-88-1
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
[scFv-heavy-kappa]-trimer
Onfekafusp alfa shows a greater anticancer activity than both mTNFα and TN11mTNFα[2].
Onfekafusp alfa shows a 5 to 6 times higher activity than equimolar amounts of recombinant mTNFα and of the fusion protein TN11mTNFα in cytotoxic assay on L-M mouse fibroblasts[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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[scFv-heavy-kappa]-trimer
ELISA, FACS, Functional assay
Chemical Information
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CAS No. 1957239-88-1
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SMILES
[Onfekafusp alfa]
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Synonyms
L19TNF
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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