1. MAPK/ERK Pathway Apoptosis
  2. p38 MAPK TNF Receptor
  3. BMS-751324

BMS-751324 is a p38α MAPK inhibitor. BMS-751324 equips a precursor of carbamyl-methyl linkage, containing esters and phosphate functional groups derived from hydroxyphenylacetic acid (HPA). BMS-751324 effectively inhibits foot swelling and LPS-induced TNFα production in an arthritic rat model.

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BMS-751324 Chemical Structure

BMS-751324 Chemical Structure

CAS No. : 948842-66-8

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Description

BMS-751324 is a p38α MAPK inhibitor. BMS-751324 equips a precursor of carbamyl-methyl linkage, containing esters and phosphate functional groups derived from hydroxyphenylacetic acid (HPA). BMS-751324 effectively inhibits foot swelling and LPS-induced TNFα production in an arthritic rat model[1].

In Vitro

BMS-751324 (10 μM; 0-60 min) can be hydrolyzed by alkaline phosphatase (human placental ALP), instead of esterase [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

BMS-751324 (1 mg/kg, 3mg/kg; p.o.; twice daily for 1 week) inhibits paw swelling in rat adjuvant arthritis model, as well as (1 mg/kg, 3mg/kg; p.o.; single dose) inhibiting LPS-induced TNFα production[1].
BMS-751324 (1 mg/kg-100 mg/kg for rat, 10 or 30 mg/kg for monkey with 5 mL/kg of methocel suspension; p.o.; single dose) exhibits a bio-conversion in animals[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

694.63

Formula

C32H35N6O10P

CAS No.
Unlabeled CAS

SMILES

CC1=CC=C(C(NC2CC2)=O)C=C1NC3=NC=NN4C3=C(C)C(C(N(C(OCOC(CC5=CC=C(OP(O)(O)=O)C=C5)=O)=O)CCC)=O)=C4

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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BMS-751324 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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BMS-751324
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HY-18759
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