2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Landiolol hydrochloride

Landiolol hydrochloride  (Synonyms: ONO1101 hydrochloride)

Cat. No.: HY-100607A Purity: 99.65%
COA Handling Instructions

Landiolol hydrochloride (ONO1101 hydrochloride) is a highly beta1 selective ultra-short acting beta-blocker (β1/β2 selectivity = 255:1, a half-life of 4 min)， acts as an adrenoceptor antagonist.

For research use only. We do not sell to patients.

Landiolol hydrochloride Chemical Structure

Landiolol hydrochloride Chemical Structure

CAS No. : 144481-98-1

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 60 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 60 In-stock
Solid
5 mg USD 50 In-stock
10 mg USD 70 In-stock
50 mg   Get quote  
100 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Landiolol hydrochloride Related Antibodies

Top Publications Citing Use of Products

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α adrenergic receptor β adrenergic receptor

  • Biological Activity

  • Purity & Documentation

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Description

Landiolol hydrochloride (ONO1101 hydrochloride) is a highly beta1 selective ultra-short acting beta-blocker (β1/β2 selectivity = 255:1, a half-life of 4 min)， acts as an adrenoceptor antagonist[1].

IC50 & Target

beta-adrenergic receptor[1]
Clinical Trial
Molecular Weight

546.05

Appearance

Solid

Formula

C25H40ClN3O8
CAS No.
SMILES

O=C(OC[C@H]1OC(C)(C)OC1)CCC2=CC=C(OC[C@@H](O)CNCCNC(N3CCOCC3)=O)C=C2.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (457.83 mM; Need ultrasonic)

H2O : ≥ 100 mg/mL (183.13 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8313 mL 9.1567 mL 18.3133 mL
5 mM 0.3663 mL 1.8313 mL 3.6627 mL
10 mM 0.1831 mL 0.9157 mL 1.8313 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.81 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.81 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.81 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.96%

COA (243 KB) LCMS (109 KB)

Handling Instructions (2659 KB)
References
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Landiolol hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Landiolol144481-98-1ONO1101ONO 1101ONO-1101Adrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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