TLR8 agonist 9
TLR8 agonist 9 (Compound II-77) is an agonist for Toll-like receptor 8 (TLR8) with EC50 of 0.25-1 μM. TLR8 agonist 9 is stable in human and murine plasma, induces secretion of cytokines TNFα, with EC50 <1 μM. TLR8 agonist 9 exhibits antitumor activity in MC38-HER2 xenograft mouse model with a tumor growth inhibition (TGI) rate of 97%.
For research use only. We do not sell to patients.
- CAS No.: 3034750-61-0
- Formula: C38H43N7O8
- Molecular Weight:725.79
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
TLR8 |
Chemical Information
-
CAS No. 3034750-61-0
-
Molecular Weight 725.79
-
Formula C38H43N7O8
-
SMILES
O=C(C=CC1=O)N1CC2OCC(C(N3CCC4=NC=C(NC(C5(CC5)C6=CC=C7C(N=C(N)CC(C(N(CCC)CCO)=O)=C7)=C6)=O)C=C4C3)=O)CO2
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz