Anti-inflammatory agent 118 

Anti-inflammatory agent 118 is a bergenin derivative with anti-inflammatory activity. Anti-inflammatory agent 118 inhibits the expression of iNOS through negative feedback regulation mediated by NO release, while blocking the phosphorylation of p65 protein and reducing the secretion levels of two pro-inflammatory cytokines, TNF-α and IL-6. Anti-inflammatory agent 118 can be used for the research of inflammation-related diseases^[1].

Anti-inflammatory agent 118 (compound I8) (10-40 μM; 24 h) shows low cytotoxicity in RAW264.7 cells, with no significant toxicity at 10 μM and moderate toxicity at higher concentrations up to 40 μM^[1].
Anti-inflammatory agent 118 (10 μM; 2 h pre-incubation, 24 h LPS stimulation) potently inhibits LPS-induced NO, TNF-α, and IL-6 production in RAW264.7 cells, with particularly strong inhibition of IL-6^[1].
Anti-inflammatory agent 118 (10 μM) releases moderate amounts of bioactive NO in RAW264.7 cells without LPS stimulation^[1].
Anti-inflammatory agent 118 (1.25-20 μM; 2 h pre-incubation, 24 h LPS stimulation for fluorescence assay, 18 h LPS stimulation for Western blotting) inhibits LPS-induced iNOS expression in RAW264.7 cells in a dose-dependent manner^[1].
Anti-inflammatory agent 118 (5-20 μM; 2 h pre-incubation, 18 h LPS stimulation) inhibits LPS-induced p65 phosphorylation in RAW264.7 cells in a dose-dependent manner, with the strongest effect at 20 μM, though lower concentrations are less potent than the positive control 1400W (HY-18730)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

623.58

C₂₇H₂₉NO₁₄S

[O-][N+]1=C(S(=O)(C2=CC=CC=C2)=O)C(OCCCCOC3=C(OC)C(O)=CC4=C3[C@@]5([H])[C@]([C@@H](O)[C@H](O)[C@@H](CO)O5)([H])OC4=O)=CO1

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• [1]. Yuan E, et al.. NO-donating Bergenin derivatives with enhanced anti-inflammatory activity. Bioorganic & medicinal chemistry letters. 2026 Jun 04;139:130705.