Anti-Mouse TREM2 Antibody (178)
Based on 1 Customer Validation
Anti-Mouse TREM2 Antibody (178) is an antibody targeting mouse TREM2, which blocks the binding of ligands to TREM2 and inhibits TREM2-mediated signaling pathways. Anti-Mouse TREM2 Antibody (178) inhibits the tumor growth of MCA/1956 sarcoma in mice. Anti-Mouse TREM2 Antibody (178) enhances IFNγ production by intratumoral CD8+ T cells and TNFα production by intratumoral CD4+ T cells. Anti-Mouse TREM2 Antibody (178) can be used in the research of sarcoma, colorectal cancer and breast tumors. The recommended isotype control is Rat IgG2a kappa, Isotype Control (HY-P990679).
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.92%
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Isotype
Rat IgG2a kappa
Recommend Isotype Controls
Species Reactivity
Mouse
IC50 & Target
[1]|
TREM-2 |
TNF-α |
体外実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J mice (mixed sexes, 8 weeks old at tumor injection, subcutaneous injection of 1×106 MCA/1956 sarcoma cells)[1]
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Dosage:200 μg/mouse
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Administration:i.p.; every 5 days; starting day 2 after tumor injection
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Result:Significantly reduced MCA/1956 tumor growth compared to control antibody treatment.
Induced complete tumor regression in all treated mice when combined with suboptimal anti-PD-1.
Reduced the frequency of Ly6C+MHCII- and CD64+ myeloid subsets at day 10 after tumor injection when combined with suboptimal anti-PD-1.
Reduced the representation of Ly6CᵐᵒʷMHCII-, CD206+, CD63+, and CD9+ macrophage subsets at day 24, with no change in total macrophage numbers.
Augmented IFNγ production by intratumoral CD8+ T cells and TNFα production by intratumoral CD4+ T cells via ex vivo stimulation.
Was more effective at reducing tumor growth than constitutive TREM2 deficiency.
Had no off-target effects when administered to Trem2-/- mice.
遺伝子ID
アクセッション番号
Q99NH8
Target
TREM-2
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
アプリケーション
Flow cytometry; ELISA; in vitro TREM-2 blockade; in vivo TREM-2 blockade
化学情報
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性状 Liquid
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Color Colorless to light yellow
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SMILES
[Anti-Mouse TREM2 Antibody (178)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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データシート (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Anti-Mouse TREM2 Antibody (178) 関連分類
HY-P991754 関連分類
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