TNF-α-IN-1
Based on 3 publication(s) in Google Scholar
TNF-α-IN-1 (Compound I-7) is a TNF-α inhibitor. TNF-α-IN-1 can be studied in research for cancers, heart disease, autoimmune disease and infections.
For research use only. We do not sell to patients.
- Purity: 99.20%
- CAS No.: 444287-49-4
- Formula: C16H14ClN3O5
- Molecular Weight:363.75
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Anti-Infection Compound Library
HY-L002
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Immunology/Inflammation Compound Library
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Publications Citing Use of MedChemExpress (MCE) TNF-α-IN-1
More
Biological Activity
TNF-α[1]
Chemical Information
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CAS No. 444287-49-4
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Appearance Solid
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Molecular Weight 363.75
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Formula C16H14ClN3O5
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Color Light yellow to yellow
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SMILES
O=C(NCC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CCl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (3)
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Journal Impact Factor
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Most Recent
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Appl Bionics Biomech
Inhibition of TNF- α and JNK Signaling Pathway Can Reduce Paclitaxel-Induced Apoptosis of Mouse Cardiomyocytes. [Abstract]2022 Aug 16:2022:8460121. PMID: 36016921 -
Solvent & Solubility
DMSO : 200 mg/mL (549.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (13.75 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (276 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7491 mL | 13.7457 mL | 27.4914 mL | 68.7285 mL |
| 5 mM | 0.5498 mL | 2.7491 mL | 5.4983 mL | 13.7457 mL | |
| 10 mM | 0.2749 mL | 1.3746 mL | 2.7491 mL | 6.8729 mL | |
| 15 mM | 0.1833 mL | 0.9164 mL | 1.8328 mL | 4.5819 mL | |
| 20 mM | 0.1375 mL | 0.6873 mL | 1.3746 mL | 3.4364 mL | |
| 25 mM | 0.1100 mL | 0.5498 mL | 1.0997 mL | 2.7491 mL | |
| 30 mM | 0.0916 mL | 0.4582 mL | 0.9164 mL | 2.2910 mL | |
| 40 mM | 0.0687 mL | 0.3436 mL | 0.6873 mL | 1.7182 mL | |
| 50 mM | 0.0550 mL | 0.2749 mL | 0.5498 mL | 1.3746 mL | |
| 60 mM | 0.0458 mL | 0.2291 mL | 0.4582 mL | 1.1455 mL | |
| 80 mM | 0.0344 mL | 0.1718 mL | 0.3436 mL | 0.8591 mL | |
| 100 mM | 0.0275 mL | 0.1375 mL | 0.2749 mL | 0.6873 mL |
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