NS-6740 hydrochloride 

NS-6740 hydrochloride is a partial agonist of α7 nicotinic acetylcholine receptor (α7 nAChR) with an IC₅₀ of 3 nM. NS-6740 hydrochloride also acts as a potent modulator of the cholinergic anti-inflammatory pathway. NS-6740 hydrochloride alters the signaling pattern of α7 in an ion channel-independent manner, thereby reducing synaptic function. NS-6740 hydrochloride induces the desensitized state of α7 nAChR. NS-6740 hydrochloride generates robust nAChR-mediated currents. NS-6740 hydrochloride reduces LPS (HY-D1056)-induced TNF-α release from microglia. NS-6740 hydrochloride can be used in the research of neuroinflammation and neuropathic pain^[1][2].

NS-6740 (0.01-100 μM; 4.5 h) hydrochloride reduces LPS-induced TNF-α release from primary rat microglia-enriched cultures, with significant inhibition at 25 μM and complete inhibition at 50 and 100 μM^[1].
NS-6740 (5 μM; 60 s) hydrochloride induces persistent desensitization of human α7 nAChRs expressed in Xenopus laevis oocytes, blocking ACh responses while leaving receptors responsive to activation by the positive allosteric modulator PNU-120596 (HY-12152)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

400.82

C₁₉H₂₀ClF₃N₂O₂

753499-14-8

O=C(N1CCN2CCC1CC2)C3=CC=C(C4=CC(C(F)(F)F)=CC=C4)O3.Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Thomsen MS, et al. The α7 nicotinic acetylcholine receptor ligands methyllycaconitine, NS6740 and GTS-21 reduce lipopolysaccharide-induced TNF-α release from microglia. J Neuroimmunol. 2012;251(1-2):65-72.  [Content Brief]

  [2]. Papke RL, et al. NS6740, an α7 nicotinic acetylcholine receptor silent agonist, disrupts hippocampal synaptic plasticity. Neurosci Lett. 2018;677:6-13.  [Content Brief]